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Assay Detail

CHEMBL3068434

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against Homo sapiens (human) HT-29 cells after 72 hr by MTT assay
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HT-29
Confidence 1 — Organism
Curated By Autocuration

Target

HT-29 (CHEMBL384)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and crystal structure of chalcones as well as on cytotoxicity and antibacterial properties
Wu J, Wang C, Cai Y, Peng J, Liang D, Zhao Y, Yang S, Li X, Wu X, Liang G
Med Chem Res (2012) 21 : 444 -452
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 40 4.49 5.01

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL185 FLUOROURACIL 4.0 1 5.01
CHEMBL138650 1 4.95
CHEMBL2236842 1 4.86
CHEMBL1935207 1 4.81
CHEMBL337821 1 4.73
CHEMBL2236850 1 4.73
CHEMBL137846 1 4.72
CHEMBL595846 1 4.72
CHEMBL2236857 1 4.62
CHEMBL7747 4-HYDROXYCHALCONE 1 4.61
CHEMBL2236849 1 4.59
CHEMBL2236856 1 4.58
CHEMBL2236848 1 4.45
CHEMBL2236851 1 4.45
CHEMBL1339821 1 4.44
CHEMBL2236852 1 4.40
CHEMBL2013139 1 4.38
CHEMBL1801961 1 4.37
CHEMBL2236853 1 4.37
CHEMBL2236859 1 4.37
CHEMBL2236846 1 4.36
CHEMBL2236863 1 4.32
CHEMBL2236860 1 4.31
CHEMBL277300 1 4.30
CHEMBL2236845 1 4.27
CHEMBL36619 1 4.26
CHEMBL2236858 1 4.25
CHEMBL2236861 1 4.22
CHEMBL593439 1 4.18
CHEMBL513742 1 4.16

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL185 FLUOROURACIL IC50 = 9720.0 nM 5.01
CHEMBL138650 IC50 = 11130.0 nM 4.95
CHEMBL2236842 IC50 = 13950.0 nM 4.86
CHEMBL1935207 IC50 = 15450.0 nM 4.81
CHEMBL337821 IC50 = 18560.0 nM 4.73
CHEMBL2236850 IC50 = 18690.0 nM 4.73
CHEMBL137846 IC50 = 18870.0 nM 4.72
CHEMBL595846 IC50 = 18870.0 nM 4.72
CHEMBL2236857 IC50 = 24190.0 nM 4.62
CHEMBL7747 4-HYDROXYCHALCONE IC50 = 24600.0 nM 4.61
CHEMBL2236849 IC50 = 25740.0 nM 4.59
CHEMBL2236856 IC50 = 26250.0 nM 4.58
CHEMBL2236848 IC50 = 35400.0 nM 4.45
CHEMBL2236851 IC50 = 35860.0 nM 4.45
CHEMBL1339821 IC50 = 36430.0 nM 4.44
CHEMBL2236852 IC50 = 39980.0 nM 4.40
CHEMBL2013139 IC50 = 41740.0 nM 4.38
CHEMBL1801961 IC50 = 42860.0 nM 4.37
CHEMBL2236853 IC50 = 42360.0 nM 4.37
CHEMBL2236859 IC50 = 42780.0 nM 4.37
CHEMBL2236846 IC50 = 43740.0 nM 4.36
CHEMBL2236863 IC50 = 47820.0 nM 4.32
CHEMBL2236860 IC50 = 49060.0 nM 4.31
CHEMBL277300 IC50 = 49830.0 nM 4.30
CHEMBL2236845 IC50 = 53200.0 nM 4.27
CHEMBL36619 IC50 = 54620.0 nM 4.26
CHEMBL2236858 IC50 = 55680.0 nM 4.25
CHEMBL2236861 IC50 = 59540.0 nM 4.22
CHEMBL593439 IC50 = 65500.0 nM 4.18
CHEMBL513742 IC50 = 69580.0 nM 4.16
CHEMBL2236844 IC50 - -
CHEMBL469331 IC50 - -
CHEMBL2236843 IC50 - -
CHEMBL143265 IC50 - -
CHEMBL512524 IC50 - -
CHEMBL2236855 IC50 - -
CHEMBL2236854 IC50 - -
CHEMBL144626 IC50 = 130650.0 nM -
CHEMBL2236862 IC50 = 101040.0 nM -
CHEMBL2236847 IC50 - -