Assay Detail
Binding
CHEMBL3068967
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Competitive inhibition of Glycine max (soybean) 15-lipoxygenase activity using linoleic acid as substrate by Lineweaver-burk plot analysis
8
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Glycine max |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis of new series of pyrimido[4,5-b][1,4] benzothiazines as 15-lipoxygenase inhibitors and study of their inhibitory mechanism
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.55 | 5.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2296824 | — | — | 1 | 5.05 |
| CHEMBL437540 | — | — | 2 | 4.71 |
| CHEMBL2296821 | — | — | 1 | 4.06 |
| CHEMBL2296823 | — | — | 1 | - |
| CHEMBL2296822 | — | — | 1 | - |
| CHEMBL2296820 | — | — | 1 | - |
| CHEMBL2296819 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2296824 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL437540 | — | IC50 | = | 19500.0 | nM | 4.71 |
| CHEMBL437540 | — | IC50 | = | 41700.0 | nM | 4.38 |
| CHEMBL2296821 | — | IC50 | = | 86300.0 | nM | 4.06 |
| CHEMBL2296823 | — | IC50 | = | 403700.0 | nM | - |
| CHEMBL2296822 | — | IC50 | = | 726400.0 | nM | - |
| CHEMBL2296820 | — | IC50 | = | 121200.0 | nM | - |
| CHEMBL2296819 | — | IC50 | = | 611000.0 | nM | - |