Assay Detail
Binding
CHEMBL3068968
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Glycine max (soybean) 15-lipoxygenase activity assessed as decrease in peroxide formation using linoleic acid as substrate preincubated with enzyme for 5 min prior to substrate addition measured after 7 min by MBTH-DMAB method
8
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Glycine max |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis of new series of pyrimido[4,5-b][1,4] benzothiazines as 15-lipoxygenase inhibitors and study of their inhibitory mechanism
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.25 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2296824 | — | — | 1 | 6.72 |
| CHEMBL437540 | — | — | 2 | 6.70 |
| CHEMBL2296821 | — | — | 1 | 6.31 |
| CHEMBL2296820 | — | — | 1 | 6.18 |
| CHEMBL2296823 | — | — | 1 | 5.93 |
| CHEMBL2296819 | — | — | 1 | 5.73 |
| CHEMBL2296822 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2296824 | — | Ki | = | 192.0 | nM | 6.72 |
| CHEMBL437540 | — | Ki | = | 198.0 | nM | 6.70 |
| CHEMBL437540 | — | Ki | = | 204.0 | nM | 6.69 |
| CHEMBL2296821 | — | Ki | = | 486.0 | nM | 6.31 |
| CHEMBL2296820 | — | Ki | = | 662.0 | nM | 6.18 |
| CHEMBL2296823 | — | Ki | = | 1163.0 | nM | 5.93 |
| CHEMBL2296819 | — | Ki | = | 1845.0 | nM | 5.73 |
| CHEMBL2296822 | — | Ki | = | 2011.0 | nM | 5.70 |