Assay Detail
Functional
CHEMBL3069591
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Cytotoxicity against Homo sapiens (human) HuCCa1 cells assessed as inhibition of cell growth after 3 days by crystal violet staining
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HuCC-A1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Cytotoxicity and QSAR study of (thio)ureas derived from phenylalkylamines and pyridylalkylamines
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 4.74 | 6.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.19 |
| CHEMBL1321159 | — | — | 1 | 4.72 |
| CHEMBL2299368 | — | — | 1 | 4.46 |
| CHEMBL2299369 | — | — | 1 | 4.28 |
| CHEMBL1548970 | — | — | 1 | 4.07 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | - |
| CHEMBL1719884 | — | — | 1 | - |
| CHEMBL1492594 | — | — | 1 | - |
| CHEMBL2299367 | — | — | 1 | - |
| CHEMBL2299366 | — | — | 1 | - |
| CHEMBL1595295 | — | — | 1 | - |
| CHEMBL2299365 | — | — | 1 | - |
| CHEMBL2299364 | — | — | 1 | - |
| CHEMBL2299363 | — | — | 1 | - |
| CHEMBL2299362 | — | — | 1 | - |
| CHEMBL1360165 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL1321159 | — | IC50 | = | 19080.0 | nM | 4.72 |
| CHEMBL2299368 | — | IC50 | = | 34240.0 | nM | 4.46 |
| CHEMBL2299369 | — | IC50 | = | 52580.0 | nM | 4.28 |
| CHEMBL1548970 | — | IC50 | = | 84250.0 | nM | 4.07 |
| CHEMBL44657 | ETOPOSIDE | IC50 | - | — | - | |
| CHEMBL1719884 | — | IC50 | > | 191050.0 | nM | - |
| CHEMBL1492594 | — | IC50 | > | 180000.0 | nM | - |
| CHEMBL2299367 | — | IC50 | > | 173420.0 | nM | - |
| CHEMBL2299366 | — | IC50 | > | 181340.0 | nM | - |
| CHEMBL1595295 | — | IC50 | > | 171350.0 | nM | - |
| CHEMBL2299365 | — | IC50 | > | 165370.0 | nM | - |
| CHEMBL2299364 | — | IC50 | > | 149340.0 | nM | - |
| CHEMBL2299363 | — | IC50 | = | 139230.0 | nM | - |
| CHEMBL2299362 | — | IC50 | > | 138340.0 | nM | - |
| CHEMBL1360165 | — | IC50 | > | 181980.0 | nM | - |