Assay Detail
Binding
CHEMBL3069689
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Inhibition of Homo sapiens (human) endothelin converting enzyme-1
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Ligand-based drug design for human endothelin converting enzyme-1 inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 40 | 6.96 | 8.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL102527 | — | — | 1 | 8.01 |
| CHEMBL2297552 | — | — | 1 | 7.96 |
| CHEMBL2297562 | — | — | 1 | 7.96 |
| CHEMBL2297556 | — | — | 1 | 7.72 |
| CHEMBL319463 | — | — | 1 | 7.64 |
| CHEMBL421021 | — | — | 1 | 7.62 |
| CHEMBL102815 | — | — | 1 | 7.57 |
| CHEMBL103327 | — | — | 1 | 7.52 |
| CHEMBL2297564 | — | — | 1 | 7.40 |
| CHEMBL421586 | — | — | 1 | 7.39 |
| CHEMBL105054 | — | — | 1 | 7.37 |
| CHEMBL320400 | — | — | 1 | 7.31 |
| CHEMBL2297554 | — | — | 1 | 7.27 |
| CHEMBL103378 | — | — | 1 | 7.26 |
| CHEMBL104617 | — | — | 1 | 7.25 |
| CHEMBL104814 | — | — | 1 | 7.11 |
| CHEMBL102795 | — | — | 1 | 7.09 |
| CHEMBL320471 | — | — | 1 | 7.01 |
| CHEMBL2297558 | — | — | 1 | 7.01 |
| CHEMBL2297559 | — | — | 1 | 6.92 |
| CHEMBL419725 | — | — | 1 | 6.89 |
| CHEMBL2297545 | — | — | 1 | 6.89 |
| CHEMBL2297563 | — | — | 1 | 6.85 |
| CHEMBL2297555 | — | — | 1 | 6.77 |
| CHEMBL2297543 | — | — | 1 | 6.75 |
| CHEMBL2297561 | — | — | 1 | 6.70 |
| CHEMBL2297557 | — | — | 1 | 6.68 |
| CHEMBL2297553 | — | — | 1 | 6.62 |
| CHEMBL2297565 | — | — | 1 | 6.55 |
| CHEMBL2297546 | — | — | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL102527 | — | IC50 | = | 9.795 | nM | 8.01 |
| CHEMBL2297552 | — | IC50 | = | 10.99 | nM | 7.96 |
| CHEMBL2297562 | — | IC50 | = | 11.02 | nM | 7.96 |
| CHEMBL2297556 | — | IC50 | = | 19.01 | nM | 7.72 |
| CHEMBL319463 | — | IC50 | = | 23.01 | nM | 7.64 |
| CHEMBL421021 | — | IC50 | = | 23.99 | nM | 7.62 |
| CHEMBL102815 | — | IC50 | = | 26.98 | nM | 7.57 |
| CHEMBL103327 | — | IC50 | = | 29.99 | nM | 7.52 |
| CHEMBL2297564 | — | IC50 | = | 39.99 | nM | 7.40 |
| CHEMBL421586 | — | IC50 | = | 41.02 | nM | 7.39 |
| CHEMBL105054 | — | IC50 | = | 42.95 | nM | 7.37 |
| CHEMBL320400 | — | IC50 | = | 48.98 | nM | 7.31 |
| CHEMBL2297554 | — | IC50 | = | 54.08 | nM | 7.27 |
| CHEMBL103378 | — | IC50 | = | 54.95 | nM | 7.26 |
| CHEMBL104617 | — | IC50 | = | 55.98 | nM | 7.25 |
| CHEMBL104814 | — | IC50 | = | 76.91 | nM | 7.11 |
| CHEMBL102795 | — | IC50 | = | 82.04 | nM | 7.09 |
| CHEMBL320471 | — | IC50 | = | 98.17 | nM | 7.01 |
| CHEMBL2297558 | — | IC50 | = | 97.05 | nM | 7.01 |
| CHEMBL2297559 | — | IC50 | = | 119.95 | nM | 6.92 |
| CHEMBL419725 | — | IC50 | = | 130.02 | nM | 6.89 |
| CHEMBL2297545 | — | IC50 | = | 130.02 | nM | 6.89 |
| CHEMBL2297563 | — | IC50 | = | 139.96 | nM | 6.85 |
| CHEMBL2297555 | — | IC50 | = | 170.22 | nM | 6.77 |
| CHEMBL2297543 | — | IC50 | = | 179.89 | nM | 6.75 |
| CHEMBL2297561 | — | IC50 | = | 199.99 | nM | 6.70 |
| CHEMBL2297557 | — | IC50 | = | 209.89 | nM | 6.68 |
| CHEMBL2297553 | — | IC50 | = | 239.88 | nM | 6.62 |
| CHEMBL2297565 | — | IC50 | = | 279.9 | nM | 6.55 |
| CHEMBL2297546 | — | IC50 | = | 299.92 | nM | 6.52 |
| CHEMBL2297542 | — | IC50 | = | 319.89 | nM | 6.50 |
| CHEMBL2297549 | — | IC50 | = | 369.83 | nM | 6.43 |
| CHEMBL2297560 | — | IC50 | = | 410.2 | nM | 6.39 |
| CHEMBL2297544 | — | IC50 | = | 489.78 | nM | 6.31 |
| CHEMBL2297566 | — | IC50 | = | 510.5 | nM | 6.29 |
| CHEMBL2297551 | — | IC50 | = | 561.05 | nM | 6.25 |
| CHEMBL2297548 | — | IC50 | = | 650.13 | nM | 6.19 |
| CHEMBL2297550 | — | IC50 | = | 650.13 | nM | 6.19 |
| CHEMBL441817 | — | IC50 | = | 699.84 | nM | 6.16 |
| CHEMBL2297547 | — | IC50 | = | 810.96 | nM | 6.09 |