Assay Detail
Binding
CHEMBL3070212
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]IMPY from beta amyloid (unknown origin) isolated from alzheimer's patient brain homogenates after 2 hr by gamma counting analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Benzothiazole Schiff-bases as potential imaging agents for -amyloid plaques in Alzheimers disease
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.47 | 8.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2296467 | — | — | 1 | 8.36 |
| CHEMBL78012 | — | — | 1 | 8.28 |
| CHEMBL2296466 | — | — | 1 | 7.97 |
| CHEMBL2296463 | — | — | 1 | 7.46 |
| CHEMBL2296462 | — | — | 1 | 6.99 |
| CHEMBL2296464 | — | — | 1 | 6.97 |
| CHEMBL2296465 | — | — | 1 | 6.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2296467 | — | Ki | = | 4.38 | nM | 8.36 |
| CHEMBL78012 | — | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL2296466 | — | Ki | = | 10.82 | nM | 7.97 |
| CHEMBL2296463 | — | Ki | = | 34.72 | nM | 7.46 |
| CHEMBL2296462 | — | Ki | = | 102.74 | nM | 6.99 |
| CHEMBL2296464 | — | Ki | = | 106.46 | nM | 6.97 |
| CHEMBL2296465 | — | Ki | = | 514.65 | nM | 6.29 |