Assay Detail
Binding
CHEMBL3071787
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Inhibition of BuChE (unknown origin)
11
Total Activities
10
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Flavonoids as lead compounds modulating the enzyme targets in Alzheimers disease
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.57 | 5.77 |
| Ki | 1 | 5.76 | 5.76 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL518543 | KUWANON C | — | 1 | 5.77 |
| CHEMBL1770314 | NEOCYCLOMORUSIN | — | 1 | 5.77 |
| CHEMBL1770313 | CYCLOMORUSIN | — | 1 | 5.77 |
| CHEMBL1719948 | MORUSINOL | — | 1 | 5.77 |
| CHEMBL464006 | MORUSIN | — | 1 | 5.77 |
| CHEMBL1096939 | KUWANON E | — | 1 | 5.77 |
| CHEMBL2297276 | KUWANONU | — | 1 | 5.77 |
| CHEMBL2297278 | — | — | 2 | 5.76 |
| CHEMBL2297277 | — | — | 1 | 4.79 |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL518543 | KUWANON C | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL1770314 | NEOCYCLOMORUSIN | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL1770313 | CYCLOMORUSIN | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL1719948 | MORUSINOL | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL464006 | MORUSIN | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL1096939 | KUWANON E | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL2297276 | KUWANONU | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL2297278 | — | Ki | = | 1740.0 | nM | 5.76 |
| CHEMBL2297278 | — | IC50 | = | 10950.0 | nM | 4.96 |
| CHEMBL2297277 | — | IC50 | = | 16210.0 | nM | 4.79 |
| CHEMBL50 | QUERCETIN | IC50 | = | 420760.0 | nM | - |