Assay Detail
Functional
CHEMBL3072241
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Influenza A virus H3N2 infected MDCK cells assessed as reduction of virus-induced cytopathic effect after 3 days by colorimetric formazan-based MTS assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Influenza A virus H3N2 |
| Cell Type | MDCK |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 2-(5-substituted-1-((diethylamino)methyl)-2-oxoindolin-3-ylidene)-<i>N</i>-substituted-hydrazinecarbothioamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 5.83 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL959 | RIMANTADINE | 4.0 | 1 | 7.10 |
| CHEMBL660 | AMANTADINE | 4.0 | 1 | 5.82 |
| CHEMBL1229 | OSELTAMIVIR | 4.0 | 1 | 5.24 |
| CHEMBL1643 | RIBAVIRIN | 4.0 | 1 | 5.17 |
| CHEMBL2296652 | — | — | 1 | - |
| CHEMBL2296651 | — | — | 1 | - |
| CHEMBL2296650 | — | — | 1 | - |
| CHEMBL2296649 | — | — | 1 | - |
| CHEMBL2296648 | — | — | 1 | - |
| CHEMBL2296647 | — | — | 1 | - |
| CHEMBL2296646 | — | — | 1 | - |
| CHEMBL2296654 | — | — | 1 | - |
| CHEMBL2296653 | — | — | 1 | - |
| CHEMBL2296655 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL959 | RIMANTADINE | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL660 | AMANTADINE | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL1229 | OSELTAMIVIR | EC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL1643 | RIBAVIRIN | EC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL2296652 | — | EC50 | > | 800.0 | nM | - |
| CHEMBL2296651 | — | EC50 | > | 800.0 | nM | - |
| CHEMBL2296650 | — | EC50 | > | 800.0 | nM | - |
| CHEMBL2296649 | — | EC50 | > | 800.0 | nM | - |
| CHEMBL2296648 | — | EC50 | > | 160.0 | nM | - |
| CHEMBL2296647 | — | EC50 | > | 800.0 | nM | - |
| CHEMBL2296646 | — | EC50 | > | 160.0 | nM | - |
| CHEMBL2296654 | — | EC50 | > | 160.0 | nM | - |
| CHEMBL2296653 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL2296655 | — | EC50 | > | 20000.0 | nM | - |