Assay Detail
Binding
CHEMBL3072653
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Inhibition of CK1 (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of new potent inhibitors of CK1 and CDK5, two kinases involved in Alzheimers disease
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.44 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL361708 | HYMENIALDISINE | — | 1 | 7.52 |
| CHEMBL306226 | BENZIMIDAZOLE | -1.0 | 1 | 7.40 |
| CHEMBL15605 | HYDROCHLORTHIAZIDE | — | 1 | 7.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL361708 | HYMENIALDISINE | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL306226 | BENZIMIDAZOLE | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL15605 | HYDROCHLORTHIAZIDE | IC50 | = | 40.0 | nM | 7.40 |