Compound Detail
CHEMBL15605
HYDROCHLORTHIAZIDE Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL15605 |
| Name | HYDROCHLORTHIAZIDE |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FZWLAAWBMGSTSO-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
85.1
MW (Da)
1.14
ALogP
2
HBA
0
HBD
12.9
PSA (Ų)
0.46
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 7.4 | 7.4 | 40.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 40.0 | nM | 7.4 | Inhibition of CK1 (unknown origin) | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 556774 | 10.1021/jm00211a035 | Acetylcholinesterase | 4 |
| 7199089 | 10.1021/jm00142a006 | Thromboxane-A synthase | 1 |
| 22533875 | 10.1021/jm300343m | No relevant target | 1 |
| - | 10.1007/s00044-012-0334-1 | Unchecked | 1 |
| 556774 | 10.1021/jm00211a035 | No relevant target | 1 |
| 32208685 | 10.1021/acs.jmedchem.9b01245 | No relevant target | 1 |
Data from ChEMBL 36 via Core Engine