Assay Detail
Binding
CHEMBL3072690
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Inhibition of Homo sapiens (human) PTP1B expressed in Escherichia coli using PNPP as substrate
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Pharmacophore modeling and 3D QSAR analysis of isothiazolidinedione derivatives as PTP1B inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 4.40 | 4.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1765347 | — | — | 1 | 4.40 |
| CHEMBL2297013 | — | — | 1 | - |
| CHEMBL382311 | — | — | 1 | - |
| CHEMBL2296750 | — | — | 1 | - |
| CHEMBL2296751 | — | — | 1 | - |
| CHEMBL2296752 | — | — | 1 | - |
| CHEMBL2296753 | — | — | 1 | - |
| CHEMBL2297004 | — | — | 1 | - |
| CHEMBL2297005 | — | — | 1 | - |
| CHEMBL2297006 | — | — | 1 | - |
| CHEMBL2297007 | — | — | 1 | - |
| CHEMBL2297008 | — | — | 1 | - |
| CHEMBL2297009 | — | — | 1 | - |
| CHEMBL2297010 | — | — | 1 | - |
| CHEMBL2297012 | — | — | 1 | - |
| CHEMBL2297014 | — | — | 1 | - |
| CHEMBL2297015 | — | — | 1 | - |
| CHEMBL2295854 | — | — | 1 | - |
| CHEMBL2297016 | — | — | 1 | - |
| CHEMBL2297017 | — | — | 1 | - |
| CHEMBL2297020 | — | — | 1 | - |
| CHEMBL2297018 | — | — | 1 | - |
| CHEMBL2297019 | — | — | 1 | - |
| CHEMBL196526 | — | — | 1 | - |
| CHEMBL373105 | — | — | 1 | - |
| CHEMBL193691 | — | — | 1 | - |
| CHEMBL2297011 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1765347 | — | IC50 | = | 39994.47 | nM | 4.40 |
| CHEMBL2297013 | — | IC50 | = | 660693.45 | nM | - |
| CHEMBL382311 | — | IC50 | = | 179887.09 | nM | - |
| CHEMBL2296750 | — | IC50 | = | 5997910.76 | nM | - |
| CHEMBL2296751 | — | IC50 | = | 1499684.84 | nM | - |
| CHEMBL2296752 | — | IC50 | = | 14996848.36 | nM | - |
| CHEMBL2296753 | — | IC50 | = | 1199499.3 | nM | - |
| CHEMBL2297004 | — | IC50 | = | 69984199.6 | nM | - |
| CHEMBL2297005 | — | IC50 | = | 100000000.0 | nM | - |
| CHEMBL2297006 | — | IC50 | = | 100000000.0 | nM | - |
| CHEMBL2297007 | — | IC50 | = | 339625.27 | nM | - |
| CHEMBL2297008 | — | IC50 | = | 169824.37 | nM | - |
| CHEMBL2297009 | — | IC50 | = | 169824.37 | nM | - |
| CHEMBL2297010 | — | IC50 | = | 169824.37 | nM | - |
| CHEMBL2297012 | — | IC50 | = | 149968.48 | nM | - |
| CHEMBL2297014 | — | IC50 | = | 100000000.0 | nM | - |
| CHEMBL2297015 | — | IC50 | = | 2697739.43 | nM | - |
| CHEMBL2295854 | — | IC50 | = | 1399587.32 | nM | - |
| CHEMBL2297016 | — | IC50 | = | 1599558.03 | nM | - |
| CHEMBL2297017 | — | IC50 | = | 790678.63 | nM | - |
| CHEMBL2297020 | — | IC50 | = | 1000000.0 | nM | - |
| CHEMBL2297018 | — | IC50 | = | 1798870.92 | nM | - |
| CHEMBL2297019 | — | IC50 | = | 100000000.0 | nM | - |
| CHEMBL196526 | — | IC50 | = | 1749846.69 | nM | - |
| CHEMBL373105 | — | IC50 | = | 15995580.29 | nM | - |
| CHEMBL193691 | — | IC50 | = | 2999162.52 | nM | - |
| CHEMBL2297011 | — | IC50 | = | 179887.09 | nM | - |