Assay Detail
Functional
CHEMBL3073517
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Cytotoxicity against Homo sapiens (human) HCT15 cells assessed as cell viability after 72 hr by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-15 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Potential cytotoxic and apoptosis inducing agents: synthesis and evaluation of methoxy-substituted chalcones against human lung and cervical cancers
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.25 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL144152 | — | — | 1 | 7.68 |
| CHEMBL2296851 | — | — | 1 | 7.50 |
| CHEMBL2296850 | — | — | 1 | 7.30 |
| CHEMBL2296847 | — | — | 1 | 7.26 |
| CHEMBL2296853 | — | — | 1 | 7.26 |
| CHEMBL2296852 | — | — | 1 | 7.25 |
| CHEMBL2296854 | — | — | 1 | 7.21 |
| CHEMBL2296848 | — | — | 1 | 7.14 |
| CHEMBL2296849 | — | — | 1 | 7.14 |
| CHEMBL2296855 | — | — | 1 | 7.10 |
| CHEMBL2296856 | — | — | 1 | 6.87 |
| CHEMBL2296846 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL144152 | — | IC50 | = | 20.9 | nM | 7.68 |
| CHEMBL2296851 | — | IC50 | = | 31.7 | nM | 7.50 |
| CHEMBL2296850 | — | IC50 | = | 50.5 | nM | 7.30 |
| CHEMBL2296847 | — | IC50 | = | 55.3 | nM | 7.26 |
| CHEMBL2296853 | — | IC50 | = | 55.3 | nM | 7.26 |
| CHEMBL2296852 | — | IC50 | = | 55.9 | nM | 7.25 |
| CHEMBL2296854 | — | IC50 | = | 61.1 | nM | 7.21 |
| CHEMBL2296848 | — | IC50 | = | 72.2 | nM | 7.14 |
| CHEMBL2296849 | — | IC50 | = | 72.2 | nM | 7.14 |
| CHEMBL2296855 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL2296856 | — | IC50 | = | 134.4 | nM | 6.87 |
| CHEMBL2296846 | — | IC50 | > | 100000.0 | nM | - |