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Assay Detail

CHEMBL3073853

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to Nav 1.2 (unknown origin)
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Sodium channel protein type 2 subunit alpha (CHEMBL4187)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Docking, synthesis, and pharmacological evaluation of isoindoline derivatives as anticonvulsant agents
Davood A, Amini M, Azimidoost L, Rahmatpour S, Nikbakht A, Iman M, Shafaroodi H, Ansari A
Med Chem Res (2013) 22 : 3177 -3184
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 12 4.44 4.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL520850 1 4.80
CHEMBL2298874 1 4.74
CHEMBL2298877 1 4.69
CHEMBL2430974 1 4.66
CHEMBL312097 1 4.30
CHEMBL16 PHENYTOIN 4.0 1 4.27
CHEMBL2298875 1 4.21
CHEMBL27783 1 4.18
CHEMBL1972820 1 4.11
CHEMBL2298876 1 -
CHEMBL419845 N-PHTHALOYLANTHRANILIC ACID 1 -
CHEMBL97672 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL520850 Ki = 16010.0 nM 4.80
CHEMBL2298874 Ki = 18270.0 nM 4.74
CHEMBL2298877 Ki = 20300.0 nM 4.69
CHEMBL2430974 Ki = 21800.0 nM 4.66
CHEMBL312097 Ki = 50400.0 nM 4.30
CHEMBL16 PHENYTOIN Ki = 53370.0 nM 4.27
CHEMBL2298875 Ki = 61070.0 nM 4.21
CHEMBL27783 Ki = 65560.0 nM 4.18
CHEMBL1972820 Ki = 78420.0 nM 4.11
CHEMBL2298876 Ki = 108070.0 nM -
CHEMBL419845 N-PHTHALOYLANTHRANILIC ACID Ki = 337800.0 nM -
CHEMBL97672 Ki = 133560.0 nM -