Assay Detail
Functional
CHEMBL3074359
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Cytotoxicity against Homo sapiens (human) CEM cells assessed as growth inhibition after 72 hr by coulter counter analysis
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 2-(5-substituted-1-((diethylamino)methyl)-2-oxoindolin-3-ylidene)-<i>N</i>-substituted-hydrazinecarbothioamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.03 | 5.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2296647 | — | — | 1 | 5.72 |
| CHEMBL852 | MELPHALAN | 4.0 | 1 | 5.66 |
| CHEMBL2296652 | — | — | 1 | 5.34 |
| CHEMBL2296651 | — | — | 1 | 5.16 |
| CHEMBL2296646 | — | — | 1 | 5.00 |
| CHEMBL2296654 | — | — | 1 | 4.96 |
| CHEMBL2296648 | — | — | 1 | 4.92 |
| CHEMBL2296649 | — | — | 1 | 4.40 |
| CHEMBL2296653 | — | — | 1 | 4.15 |
| CHEMBL2296650 | — | — | 1 | - |
| CHEMBL2296655 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2296647 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL852 | MELPHALAN | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL2296652 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL2296651 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL2296646 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL2296654 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL2296648 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL2296649 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL2296653 | — | IC50 | = | 71000.0 | nM | 4.15 |
| CHEMBL2296650 | — | IC50 | > | 125000.0 | nM | - |
| CHEMBL2296655 | — | IC50 | = | 164000.0 | nM | - |