Assay Detail
Binding
CHEMBL3075134
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]alpha-bungarotoxin from nAChR in honeybee head membrane after 60 min by scintillation counting
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Apis mellifera |
| Tissue | Head |
| Subcellular | Membrane |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Binding of Nicotinoids and the Related Compounds to the Insect Nicotinic Acetyicholine Receptor
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 41 | 5.09 | 6.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL497939 | CYTISINICLINE | 3.0 | 1 | 6.19 |
| CHEMBL2286829 | DIHYDRONICOTYRINE | — | 1 | 5.90 |
| CHEMBL3 | NICOTINE | 4.0 | 1 | 5.83 |
| CHEMBL406819 | IMIDACLOPRID | — | 1 | 5.60 |
| CHEMBL339427 | TUBOCURARINE | 4.0 | 1 | 5.45 |
| CHEMBL280963 | DL-ANABASINE | — | 1 | 5.41 |
| CHEMBL1201329 | TRIMETHAPHAN | 4.0 | 1 | 5.24 |
| CHEMBL6200 | NORNICOTINE | 1.0 | 1 | 5.12 |
| CHEMBL122270 | LOBELINE | 2.0 | 1 | 5.04 |
| CHEMBL148489 | N-(3-PYRIDYLMETHYL)PYRROLIDINE | — | 1 | 4.84 |
| CHEMBL517712 | ATROPINE | 4.0 | 1 | 4.58 |
| CHEMBL9732 | R-NICOTINE | — | 1 | 4.36 |
| CHEMBL2287057 | — | — | 1 | 4.31 |
| CHEMBL134752 | DIMETHYLPHENYLPIPERAZINIUM | — | 1 | 4.30 |
| CHEMBL1271 | PENTOLINIUM | 4.0 | 1 | 4.14 |
| CHEMBL578211 | COTININE | 2.0 | 1 | - |
| CHEMBL2286836 | — | — | 1 | - |
| CHEMBL331904 | — | — | 1 | - |
| CHEMBL2286835 | — | — | 1 | - |
| CHEMBL2286834 | — | — | 1 | - |
| CHEMBL267936 | MECAMYLAMINE | 4.0 | 1 | - |
| CHEMBL2287063 | CONIINE | — | 1 | - |
| CHEMBL2286837 | — | — | 1 | - |
| CHEMBL14 | CARBACHOL | 4.0 | 1 | - |
| CHEMBL1190 | DECAMETHONIUM | 4.0 | 1 | - |
| CHEMBL7303 | ARECOLINE | -1.0 | 1 | - |
| CHEMBL2285758 | NEREISTOXIN | — | 1 | - |
| CHEMBL357101 | — | — | 1 | - |
| CHEMBL2286832 | — | — | 1 | - |
| CHEMBL2286833 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL497939 | CYTISINICLINE | Ki | = | 650.0 | nM | 6.19 |
| CHEMBL2286829 | DIHYDRONICOTYRINE | Ki | = | 1270.0 | nM | 5.90 |
| CHEMBL3 | NICOTINE | Ki | = | 1480.0 | nM | 5.83 |
| CHEMBL406819 | IMIDACLOPRID | Ki | = | 2530.0 | nM | 5.60 |
| CHEMBL339427 | TUBOCURARINE | Ki | = | 3570.0 | nM | 5.45 |
| CHEMBL280963 | DL-ANABASINE | Ki | = | 3910.0 | nM | 5.41 |
| CHEMBL1201329 | TRIMETHAPHAN | Ki | = | 5790.0 | nM | 5.24 |
| CHEMBL6200 | NORNICOTINE | Ki | = | 7610.0 | nM | 5.12 |
| CHEMBL122270 | LOBELINE | Ki | = | 9130.0 | nM | 5.04 |
| CHEMBL148489 | N-(3-PYRIDYLMETHYL)PYRROLIDINE | Ki | = | 14300.0 | nM | 4.84 |
| CHEMBL517712 | ATROPINE | Ki | = | 26300.0 | nM | 4.58 |
| CHEMBL9732 | R-NICOTINE | Ki | = | 43700.0 | nM | 4.36 |
| CHEMBL2287057 | — | Ki | = | 48700.0 | nM | 4.31 |
| CHEMBL134752 | DIMETHYLPHENYLPIPERAZINIUM | Ki | = | 49500.0 | nM | 4.30 |
| CHEMBL1271 | PENTOLINIUM | Ki | = | 72200.0 | nM | 4.14 |
| CHEMBL1522291 | NICOTYRINE | Ki | > | 1000000.0 | nM | - |
| CHEMBL423429 | MYOSMINE | Ki | > | 1000000.0 | nM | - |
| CHEMBL141989 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL2286831 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL2251224 | 2-(NITROMETHYLENE)IMIDAZOLIDINE | Ki | > | 1000000.0 | nM | - |
| CHEMBL2287062 | — | Ki | > | 500000.0 | nM | - |
| CHEMBL2287061 | — | Ki | > | 500000.0 | nM | - |
| CHEMBL2287060 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL2287059 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL2287058 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL2286838 | — | Ki | = | 175000.0 | nM | - |
| CHEMBL578211 | COTININE | Ki | > | 1000000.0 | nM | - |
| CHEMBL2286836 | — | Ki | = | 155000.0 | nM | - |
| CHEMBL331904 | — | Ki | = | 208000.0 | nM | - |
| CHEMBL2286835 | — | Ki | = | 406000.0 | nM | - |
| CHEMBL2286834 | — | Ki | = | 103000.0 | nM | - |
| CHEMBL267936 | MECAMYLAMINE | Ki | = | 453000.0 | nM | - |
| CHEMBL2287063 | CONIINE | Ki | = | 262000.0 | nM | - |
| CHEMBL2286837 | — | Ki | = | 200000.0 | nM | - |
| CHEMBL14 | CARBACHOL | Ki | = | 175000.0 | nM | - |
| CHEMBL1190 | DECAMETHONIUM | Ki | = | 224000.0 | nM | - |
| CHEMBL7303 | ARECOLINE | Ki | = | 240000.0 | nM | - |
| CHEMBL2285758 | NEREISTOXIN | Ki | = | 254000.0 | nM | - |
| CHEMBL357101 | — | Ki | = | 377000.0 | nM | - |
| CHEMBL2286832 | — | Ki | = | 289000.0 | nM | - |
| CHEMBL2286833 | — | Ki | > | 1000000.0 | nM | - |