Compound Detail
CHEMBL1201329
TRIMETHAPHAN 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL1201329 |
| Name | TRIMETHAPHAN |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | CHQOEHPMXSHGCL-UHFFFAOYSA-N |
| Therapeutic | ✓ Yes |
3
Targets
3
Activities
2
Assay Types
0
PK Parameters
3
Publications
4
Known Names
2
Indications
Molecular Properties
365.5
MW (Da)
3.66
ALogP
1
HBA
0
HBD
23.6
PSA (Ų)
0.60
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1982 |
| Availability | Discontinued |
| Chirality | Racemic |
Indications
Hypertension Insulin Resistance
ATC Classification
C02BA01
trimetaphan
Level 1: CARDIOVASCULAR SYSTEM
Level 2: ANTIHYPERTENSIVES
Activity Summary
Ki 2 meas. best 5.56
IC50 1 meas. best 5.15
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Nicotinic acetylcholine receptor alpha 5 subunit CHEMBL2366408 | Ki | 5.56 | 5.56 | 2750.0 | 1 |
| Unchecked CHEMBL612545 | Ki | 5.24 | 5.24 | 5790.0 | 1 |
| Acetylcholine receptor subunit alpha CHEMBL3097 | IC50 | 5.15 | 5.15 | 7070.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Nicotinic acetylcholine receptor alpha 5 subunit | Ki | = | 2750.0 | nM | 5.56 | Displacement of [3H]alpha-bungarotoxin from nAChR in Musca domestica (house fly)... | - |
| Unchecked | Ki | = | 5790.0 | nM | 5.24 | Displacement of [3H]alpha-bungarotoxin from nAChR in honeybee head membrane afte... | - |
| Acetylcholine receptor subunit alpha | IC50 | = | 7070.0 | nM | 5.15 | Displacement of [3H]PCP from nAChR in Torpedo nobiliana electric organs membrane... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1584/jpestics.20.49 | Acetylcholine receptor subunit alpha | 6 |
| - | 10.1584/jpestics.17.4_231 | Unchecked | 1 |
| - | 10.1584/jpestics.17.4_231 | Nicotinic acetylcholine receptor alpha 5 subunit | 1 |
Data from ChEMBL 36 via Core Engine