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Assay Detail

CHEMBL3075191

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against Mammalian orthoreovirus 1 infected Syrian hamster BHK-21 cells assessed as protection against virus-induced cytopathogenicity treated 1 hr after viral infection measured after 3-4 days by MTT method
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mammalian orthoreovirus 1
Cell Type BHK-21
Confidence 1 — Organism
Curated By Autocuration

Target

Mammalian orthoreovirus 1 (CHEMBL612927)
Type ORGANISM
Organism Mammalian orthoreovirus 1

Publication

Syntheses and in vitro biological screening of 1-aryl-10H-[1,2,4]triazolo[3,4:3,4][1,2,4]triazino[5,6-b]indoles
Upadhyay K, Manvar A, Loddo R, Colla PL, Virsodiya V, Trivedi J, Chaniyara R, Shah A
Med Chem Res (2013) 22 : 3675 -3686
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 22 4.40 4.60

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2296720 1 4.60
CHEMBL2296704 1 4.35
CHEMBL2296702 1 4.26
CHEMBL2296721 1 -
CHEMBL2296719 1 -
CHEMBL2295851 1 -
CHEMBL2296718 1 -
CHEMBL2296717 1 -
CHEMBL2296716 1 -
CHEMBL2296715 1 -
CHEMBL2296714 1 -
CHEMBL2296713 1 -
CHEMBL2296722 1 -
CHEMBL2296711 1 -
CHEMBL2296710 1 -
CHEMBL2296709 1 -
CHEMBL2296708 1 -
CHEMBL2296707 1 -
CHEMBL2296706 1 -
CHEMBL2296705 1 -
CHEMBL2296703 1 -
CHEMBL2296712 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2296720 EC50 = 25000.0 nM 4.60
CHEMBL2296704 EC50 = 45000.0 nM 4.35
CHEMBL2296702 EC50 = 55000.0 nM 4.26
CHEMBL2296721 EC50 > 100000.0 nM -
CHEMBL2296719 EC50 > 100000.0 nM -
CHEMBL2295851 EC50 > 100000.0 nM -
CHEMBL2296718 EC50 > 100000.0 nM -
CHEMBL2296717 EC50 > 55000.0 nM -
CHEMBL2296716 EC50 > 23000.0 nM -
CHEMBL2296715 EC50 > 100000.0 nM -
CHEMBL2296714 EC50 > 30000.0 nM -
CHEMBL2296713 EC50 > 100000.0 nM -
CHEMBL2296722 EC50 > 100000.0 nM -
CHEMBL2296711 EC50 > 100000.0 nM -
CHEMBL2296710 EC50 > 100000.0 nM -
CHEMBL2296709 EC50 > 100000.0 nM -
CHEMBL2296708 EC50 > 100000.0 nM -
CHEMBL2296707 EC50 > 100000.0 nM -
CHEMBL2296706 EC50 > 100000.0 nM -
CHEMBL2296705 EC50 > 100000.0 nM -
CHEMBL2296703 EC50 > 100000.0 nM -
CHEMBL2296712 EC50 > 100000.0 nM -