Assay Detail
Functional
CHEMBL3075718
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Human herpesvirus 2 strain G infected human HEL cells assessed as reduction of virus-induced cytopathic effect after 3 days by colorimetric formazan-based MTS assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human alphaherpesvirus 2 |
| Cell Type | HEL |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 2-(5-substituted-1-((diethylamino)methyl)-2-oxoindolin-3-ylidene)-<i>N</i>-substituted-hydrazinecarbothioamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 5.62 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | 7.16 |
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | 6.16 |
| CHEMBL5314375 | CIDOFOVIR | 4.0 | 1 | 5.82 |
| CHEMBL2296648 | — | — | 1 | 4.92 |
| CHEMBL2296646 | — | — | 1 | 4.82 |
| CHEMBL2296654 | — | — | 1 | 4.82 |
| CHEMBL31634 | BRIVUDINE | 2.0 | 1 | - |
| CHEMBL2296652 | — | — | 1 | - |
| CHEMBL2296651 | — | — | 1 | - |
| CHEMBL2296650 | — | — | 1 | - |
| CHEMBL2296649 | — | — | 1 | - |
| CHEMBL2296647 | — | — | 1 | - |
| CHEMBL2296653 | — | — | 1 | - |
| CHEMBL2296655 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL182 | GANCICLOVIR | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL184 | ACYCLOVIR | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL5314375 | CIDOFOVIR | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL2296648 | — | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL2296646 | — | EC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL2296654 | — | EC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL31634 | BRIVUDINE | EC50 | = | 150000.0 | nM | - |
| CHEMBL2296652 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL2296651 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL2296650 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL2296649 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL2296647 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL2296653 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL2296655 | — | EC50 | > | 100000.0 | nM | - |