Assay Detail
Binding
CHEMBL3076141
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Inhibition of [3H]IMI binding to Drosophila melanogaster neuronal acetylcholine receptor
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Drosophila melanogaster |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Acetylcholine receptor subunit beta-like 2 (CHEMBL2366470) ↗| Type | SINGLE PROTEIN |
| Organism | Drosophila melanogaster |
Publication
Neonicotinoid insecticides: molecular features conferring selectivity for insect versus mammalian nicotinic receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.17 | 9.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2270633 | — | — | 1 | 9.43 |
| CHEMBL451432 | THIACLOPRID | — | 1 | 8.57 |
| CHEMBL406819 | IMIDACLOPRID | — | 1 | 8.34 |
| CHEMBL72675 | — | — | 1 | 6.73 |
| CHEMBL71046 | DESCYANOTHIACLOPRID | — | 1 | 6.70 |
| CHEMBL6623 | EPIBATIDINE | — | 1 | 6.37 |
| CHEMBL309804 | DESNITROIMIDACLOPRID | — | 1 | 5.82 |
| CHEMBL3 | NICOTINE | 4.0 | 1 | 5.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2270633 | — | IC50 | = | 0.37 | nM | 9.43 |
| CHEMBL451432 | THIACLOPRID | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL406819 | IMIDACLOPRID | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL72675 | — | IC50 | = | 185.0 | nM | 6.73 |
| CHEMBL71046 | DESCYANOTHIACLOPRID | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL6623 | EPIBATIDINE | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL309804 | DESNITROIMIDACLOPRID | IC50 | = | 1530.0 | nM | 5.82 |
| CHEMBL3 | NICOTINE | IC50 | = | 4000.0 | nM | 5.40 |