Assay Detail
Binding
CHEMBL3077166
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of autophosphorylation of His6-tagged EGFR cytoplasmic domain (unknown origin) expressed in Sf9 cells by DELFIA time resolved fluorometry
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, structure, and biological assay of cinnamic amides as potential EGFR kinase inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 4.95 | 6.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | 6.47 |
| CHEMBL2336355 | N-(2-METHOXYPHENYL)CINNAMAMIDE | — | 1 | 5.29 |
| CHEMBL1998736 | N-(2-FLUOROPHENYL)CINNAMAMIDE | — | 1 | 5.13 |
| CHEMBL2336357 | N-(4-METHOXYPHENYL)CINNAMAMIDE | — | 1 | 5.04 |
| CHEMBL2283248 | — | — | 1 | 5.03 |
| CHEMBL1981977 | N-(2-CHLOROPHENYL)CINNAMAMIDE | — | 1 | 5.01 |
| CHEMBL2336361 | N-(4-FLUOROPHENYL)CINNAMAMIDE | — | 1 | 5.00 |
| CHEMBL2283249 | — | — | 1 | 4.99 |
| CHEMBL2283251 | — | — | 1 | 4.93 |
| CHEMBL2336358 | N-O-TOLYLCINNAMAMIDE | — | 1 | 4.91 |
| CHEMBL2336359 | N-P-TOLYLCINNAMAMIDE | — | 1 | 4.90 |
| CHEMBL2283253 | — | — | 1 | 4.89 |
| CHEMBL2283252 | — | — | 1 | 4.88 |
| CHEMBL2336335 | N-(4-CHLOROPHENYL)CINNAMAMIDE | — | 1 | 4.86 |
| CHEMBL2283256 | — | — | 1 | 4.86 |
| CHEMBL1830131 | N-(3-CHLOROPHENYL)CINNAMAMIDE | — | 1 | 4.84 |
| CHEMBL2283245 | — | — | 1 | 4.84 |
| CHEMBL2283257 | — | — | 1 | 4.80 |
| CHEMBL2283255 | — | — | 1 | 4.79 |
| CHEMBL1830130 | N-M-TOLYLCINNAMAMIDE | — | 1 | 4.71 |
| CHEMBL1830129 | N-PHENYLCINNAMAMIDE | — | 1 | 4.63 |
| CHEMBL2283259 | N-TERT-BUTYLCINNAMAMIDE | — | 1 | 4.53 |
| CHEMBL2283258 | N-DODECYLCINNAMAMIDE | — | 1 | 4.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL553 | ERLOTINIB | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL2336355 | N-(2-METHOXYPHENYL)CINNAMAMIDE | IC50 | = | 5160.0 | nM | 5.29 |
| CHEMBL1998736 | N-(2-FLUOROPHENYL)CINNAMAMIDE | IC50 | = | 7370.0 | nM | 5.13 |
| CHEMBL2336357 | N-(4-METHOXYPHENYL)CINNAMAMIDE | IC50 | = | 9050.0 | nM | 5.04 |
| CHEMBL2283248 | — | IC50 | = | 9350.0 | nM | 5.03 |
| CHEMBL1981977 | N-(2-CHLOROPHENYL)CINNAMAMIDE | IC50 | = | 9860.0 | nM | 5.01 |
| CHEMBL2336361 | N-(4-FLUOROPHENYL)CINNAMAMIDE | IC50 | = | 10020.0 | nM | 5.00 |
| CHEMBL2283249 | — | IC50 | = | 10230.0 | nM | 4.99 |
| CHEMBL2283251 | — | IC50 | = | 11690.0 | nM | 4.93 |
| CHEMBL2336358 | N-O-TOLYLCINNAMAMIDE | IC50 | = | 12290.0 | nM | 4.91 |
| CHEMBL2336359 | N-P-TOLYLCINNAMAMIDE | IC50 | = | 12690.0 | nM | 4.90 |
| CHEMBL2283253 | — | IC50 | = | 12880.0 | nM | 4.89 |
| CHEMBL2283252 | — | IC50 | = | 13230.0 | nM | 4.88 |
| CHEMBL2336335 | N-(4-CHLOROPHENYL)CINNAMAMIDE | IC50 | = | 13710.0 | nM | 4.86 |
| CHEMBL2283256 | — | IC50 | = | 13930.0 | nM | 4.86 |
| CHEMBL1830131 | N-(3-CHLOROPHENYL)CINNAMAMIDE | IC50 | = | 14590.0 | nM | 4.84 |
| CHEMBL2283245 | — | IC50 | = | 14580.0 | nM | 4.84 |
| CHEMBL2283257 | — | IC50 | = | 15740.0 | nM | 4.80 |
| CHEMBL2283255 | — | IC50 | = | 16170.0 | nM | 4.79 |
| CHEMBL1830130 | N-M-TOLYLCINNAMAMIDE | IC50 | = | 19690.0 | nM | 4.71 |
| CHEMBL1830129 | N-PHENYLCINNAMAMIDE | IC50 | = | 23160.0 | nM | 4.63 |
| CHEMBL2283259 | N-TERT-BUTYLCINNAMAMIDE | IC50 | = | 29850.0 | nM | 4.53 |
| CHEMBL2283258 | N-DODECYLCINNAMAMIDE | IC50 | = | 38460.0 | nM | 4.42 |