Assay Detail
Functional
CHEMBL3077880
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human melanoma cells
78
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Melanoma cell |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Comparative QSAR and pharmacophore modeling of substituted 2-[2-(dimethylamino) ethyl]-1, 2-dihydro-3H-dibenz[de,h]isoquinoline-1,3-diones derivatives as anti-tumor activity
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 78 | 8.18 | 8.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL146315 | — | — | 2 | 8.33 |
| CHEMBL147556 | — | — | 2 | 8.30 |
| CHEMBL422843 | — | — | 2 | 8.29 |
| CHEMBL178168 | — | — | 2 | 8.25 |
| CHEMBL148229 | — | — | 2 | 8.24 |
| CHEMBL147428 | — | — | 2 | 8.24 |
| CHEMBL146516 | — | — | 2 | 8.23 |
| CHEMBL149619 | — | — | 2 | 8.23 |
| CHEMBL177706 | — | — | 2 | 8.22 |
| CHEMBL148027 | — | — | 2 | 8.22 |
| CHEMBL147216 | — | — | 2 | 8.22 |
| CHEMBL149184 | — | — | 2 | 8.21 |
| CHEMBL2281897 | — | — | 2 | 8.20 |
| CHEMBL439632 | — | — | 2 | 8.20 |
| CHEMBL343852 | — | — | 2 | 8.19 |
| CHEMBL146559 | — | — | 2 | 8.18 |
| CHEMBL358993 | — | — | 2 | 8.17 |
| CHEMBL345020 | — | — | 2 | 8.17 |
| CHEMBL439812 | — | — | 2 | 8.17 |
| CHEMBL146037 | — | — | 2 | 8.16 |
| CHEMBL290677 | AZONAFIDE | — | 2 | 8.15 |
| CHEMBL344310 | — | — | 2 | 8.15 |
| CHEMBL356785 | — | — | 2 | 8.15 |
| CHEMBL148263 | — | — | 2 | 8.15 |
| CHEMBL146104 | — | — | 2 | 8.15 |
| CHEMBL147576 | — | — | 2 | 8.15 |
| CHEMBL148344 | — | — | 2 | 8.15 |
| CHEMBL149293 | — | — | 2 | 8.14 |
| CHEMBL145826 | — | — | 2 | 8.14 |
| CHEMBL148281 | — | — | 2 | 8.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL146315 | — | IC50 | = | 4.69 | nM | 8.33 |
| CHEMBL147556 | — | IC50 | = | 5.06 | nM | 8.30 |
| CHEMBL422843 | — | IC50 | = | 5.12 | nM | 8.29 |
| CHEMBL178168 | — | IC50 | = | 5.61 | nM | 8.25 |
| CHEMBL148229 | — | IC50 | = | 5.69 | nM | 8.24 |
| CHEMBL147428 | — | IC50 | = | 5.73 | nM | 8.24 |
| CHEMBL149619 | — | IC50 | = | 5.92 | nM | 8.23 |
| CHEMBL146516 | — | IC50 | = | 5.92 | nM | 8.23 |
| CHEMBL177706 | — | IC50 | = | 6.01 | nM | 8.22 |
| CHEMBL148027 | — | IC50 | = | 6.02 | nM | 8.22 |
| CHEMBL147216 | — | IC50 | = | 6.08 | nM | 8.22 |
| CHEMBL149184 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL439632 | — | IC50 | = | 6.27 | nM | 8.20 |
| CHEMBL2281897 | — | IC50 | = | 6.26 | nM | 8.20 |
| CHEMBL343852 | — | IC50 | = | 6.53 | nM | 8.19 |
| CHEMBL146559 | — | IC50 | = | 6.57 | nM | 8.18 |
| CHEMBL345020 | — | IC50 | = | 6.75 | nM | 8.17 |
| CHEMBL439812 | — | IC50 | = | 6.79 | nM | 8.17 |
| CHEMBL358993 | — | IC50 | = | 6.74 | nM | 8.17 |
| CHEMBL146037 | — | IC50 | = | 6.89 | nM | 8.16 |
| CHEMBL290677 | AZONAFIDE | IC50 | = | 7.15 | nM | 8.15 |
| CHEMBL148263 | — | IC50 | = | 7.13 | nM | 8.15 |
| CHEMBL344310 | — | IC50 | = | 7.11 | nM | 8.15 |
| CHEMBL146104 | — | IC50 | = | 7.01 | nM | 8.15 |
| CHEMBL147576 | — | IC50 | = | 7.12 | nM | 8.15 |
| CHEMBL356785 | — | IC50 | = | 7.09 | nM | 8.15 |
| CHEMBL148344 | — | IC50 | = | 7.05 | nM | 8.15 |
| CHEMBL148281 | — | IC50 | = | 7.19 | nM | 8.14 |
| CHEMBL145826 | — | IC50 | = | 7.22 | nM | 8.14 |
| CHEMBL146101 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL422137 | — | IC50 | = | 7.28 | nM | 8.14 |
| CHEMBL149293 | — | IC50 | = | 7.28 | nM | 8.14 |
| CHEMBL343913 | — | IC50 | = | 7.44 | nM | 8.13 |
| CHEMBL147597 | — | IC50 | = | 7.35 | nM | 8.13 |
| CHEMBL148141 | — | IC50 | = | 7.42 | nM | 8.13 |
| CHEMBL146785 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL145869 | — | IC50 | = | 8.02 | nM | 8.10 |
| CHEMBL147372 | — | IC50 | = | 7.96 | nM | 8.10 |
| CHEMBL144014 | — | IC50 | = | 8.34 | nM | 8.08 |
| CHEMBL146516 | — | IC50 | = | 169044093.16 | nM | - |
| CHEMBL146785 | — | IC50 | = | 128233058.27 | nM | - |
| CHEMBL356785 | — | IC50 | = | 141253754.46 | nM | - |
| CHEMBL146101 | — | IC50 | = | 138995263.12 | nM | - |
| CHEMBL148281 | — | IC50 | = | 139315680.29 | nM | - |
| CHEMBL422137 | — | IC50 | = | 137404197.5 | nM | - |
| CHEMBL147576 | — | IC50 | = | 140604752.41 | nM | - |
| CHEMBL343913 | — | IC50 | = | 134586035.41 | nM | - |
| CHEMBL147372 | — | IC50 | = | 125892541.18 | nM | - |
| CHEMBL146104 | — | IC50 | = | 142889395.85 | nM | - |
| CHEMBL2281897 | — | IC50 | = | 159955802.86 | nM | - |