Assay Detail
Binding
CHEMBL3078296
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Inhibition of ALS in ALS-herbicide-susceptible Raphanus raphanistrum WARR7 (wild radish)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Raphanus raphanistrum |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A novel amino acid substitution Ala-122-Tyr in ALS confers high-level and broad resistance across ALS-inhibiting herbicides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.32 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1229721 | CHLORSULFURON | — | 1 | 8.15 |
| CHEMBL401913 | SULFOMETURON | — | 1 | 7.64 |
| CHEMBL1903400 | IMAZETHAPYR | — | 1 | 5.87 |
| CHEMBL1389671 | FLUMETSULAM | — | 1 | 5.78 |
| CHEMBL1881028 | IMAZAMOX | — | 1 | 5.32 |
| CHEMBL1621900 | IMAZAPYR | — | 1 | 5.17 |
| CHEMBL2288020 | METOSULAM | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1229721 | CHLORSULFURON | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL401913 | SULFOMETURON | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL1903400 | IMAZETHAPYR | IC50 | = | 1353.0 | nM | 5.87 |
| CHEMBL1389671 | FLUMETSULAM | IC50 | = | 1658.0 | nM | 5.78 |
| CHEMBL1881028 | IMAZAMOX | IC50 | = | 4776.0 | nM | 5.32 |
| CHEMBL1621900 | IMAZAPYR | IC50 | = | 6838.0 | nM | 5.17 |
| CHEMBL2288020 | METOSULAM | IC50 | < | 1.0 | nM | - |