Compound Detail
CHEMBL1389671
FLUMETSULAM Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL1389671 |
| Name | FLUMETSULAM |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RXCPQSJAVKGONC-UHFFFAOYSA-N |
4
Targets
7
Activities
2
Assay Types
0
PK Parameters
17
Publications
0
Known Names
Molecular Properties
325.3
MW (Da)
1.51
ALogP
6
HBA
1
HBD
89.2
PSA (Ų)
0.79
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 6 meas. best 7.5
Ki 1 meas. best 6.44
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Acetolactate synthase CHEMBL2366415 | IC50 | 7.5 | 6.765 | 31.6 | 2 |
| Acetolactate synthase, chloroplastic CHEMBL4263 | Ki | 6.44 | 6.44 | 360.0 | 1 |
| Acetolactate synthase CHEMBL2366443 | IC50 | 5.78 | 5.78 | 1658.0 | 2 |
| Unchecked CHEMBL612545 | IC50 | 5.16 | 5.09 | 6950.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Acetolactate synthase | IC50 | = | 31.6 | nM | 7.5 | Inhibition of wild type Nicotiana tabacum (tobacco) GST-tagged acetolactate synt... | 10329466 |
| Acetolactate synthase, chloroplastic | Ki | = | 360.0 | nM | 6.44 | Inhibition of wild type Arabidopsis thaliana acetolactate synthase by colorimetr... | 20598554 |
| Acetolactate synthase | IC50 | = | 938.5 | nM | 6.03 | Inhibition of wild type Nicotiana tabacum (tobacco) S4-Hra GST-tagged acetolacta... | 10329466 |
| Acetolactate synthase | IC50 | = | 1658.0 | nM | 5.78 | Inhibition of ALS in ALS-herbicide-susceptible Raphanus raphanistrum WARR33 (wil... | 22431132 |
| Acetolactate synthase | IC50 | = | 1658.0 | nM | 5.78 | Inhibition of ALS in ALS-herbicide-susceptible Raphanus raphanistrum WARR7 (wild... | 22431132 |
| Unchecked | IC50 | = | 6950.0 | nM | 5.16 | PUBCHEM_BIOASSAY: High Throughput Screening Assay used to Identify Novel Compoun... | - |
| Unchecked | IC50 | = | 9620.0 | nM | 5.02 | PUBCHEM_BIOASSAY: A High Throughput Confirmatory Assay used to Identify Novel Co... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 22431132 | 10.1002/ps.3278 | Raphanus raphanistrum | 4 |
| 20598554 | 10.1016/j.bmc.2010.06.015 | Rumex acetosa | 3 |
| 22431132 | 10.1002/ps.3278 | Acetolactate synthase | 3 |
| 20598554 | 10.1016/j.bmc.2010.06.015 | Galium aparine | 3 |
| 20598554 | 10.1016/j.bmc.2010.06.015 | Polygonum humifusum | 3 |
| 20598554 | 10.1016/j.bmc.2010.06.015 | Cerastium arvense | 3 |
| 20598554 | 10.1016/j.bmc.2010.06.015 | Cyperus iria | 3 |
| 20598554 | 10.1016/j.bmc.2010.06.015 | Chenopodium album | 3 |
| 20598554 | 10.1016/j.bmc.2010.06.015 | Amaranthus retroflexus | 3 |
| 20598554 | 10.1016/j.bmc.2010.06.015 | Eclipta prostrata | 3 |
| 10329466 | 10.1006/bbrc.1999.0708 | Acetolactate synthase | 2 |
| 20598554 | 10.1016/j.bmc.2010.06.015 | Brassica juncea | 1 |
| 20598554 | 10.1016/j.bmc.2010.06.015 | Poa annua | 1 |
| 20598554 | 10.1016/j.bmc.2010.06.015 | Digitaria sanguinalis | 1 |
| 20598554 | 10.1016/j.bmc.2010.06.015 | Echinochloa crus-galli | 1 |
| 20598554 | 10.1016/j.bmc.2010.06.015 | Acetolactate synthase, chloroplastic | 1 |
| 22431132 | 10.1002/ps.3278 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine