Assay Detail
Binding
CHEMBL3088609
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to rat KISS1R
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of novel investigational nonapeptide KISS1R agonists with testosterone-suppressive activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 29 | 9.95 | 10.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3087793 | — | — | 1 | 10.40 |
| CHEMBL3087925 | — | — | 1 | 10.38 |
| CHEMBL3087927 | — | — | 1 | 10.37 |
| CHEMBL3086282 | — | — | 1 | 10.29 |
| CHEMBL376756 | KISSPEPTIN-10 | 3.0 | 1 | 10.24 |
| CHEMBL3085809 | — | — | 1 | 10.23 |
| CHEMBL2151646 | — | — | 1 | 10.17 |
| CHEMBL3085804 | — | — | 1 | 10.15 |
| CHEMBL3087929 | — | — | 1 | 10.12 |
| CHEMBL2151654 | — | — | 1 | 10.04 |
| CHEMBL3087926 | — | — | 1 | 10.03 |
| CHEMBL3087931 | — | — | 1 | 10.02 |
| CHEMBL3086284 | KISS1-305 | — | 1 | 10.00 |
| CHEMBL2151642 | — | — | 1 | 9.96 |
| CHEMBL3086283 | — | — | 1 | 9.96 |
| CHEMBL2151652 | — | — | 1 | 9.92 |
| CHEMBL2151655 | — | — | 1 | 9.92 |
| CHEMBL3087928 | — | — | 1 | 9.92 |
| CHEMBL3086280 | — | — | 1 | 9.89 |
| CHEMBL3086286 | — | — | 1 | 9.89 |
| CHEMBL3085806 | — | — | 1 | 9.85 |
| CHEMBL3086281 | — | — | 1 | 9.82 |
| CHEMBL3085808 | — | — | 1 | 9.80 |
| CHEMBL3085807 | — | — | 1 | 9.74 |
| CHEMBL3085811 | — | — | 1 | 9.62 |
| CHEMBL3087930 | — | — | 1 | 9.60 |
| CHEMBL3086285 | — | — | 1 | 9.55 |
| CHEMBL3085810 | — | — | 1 | 9.52 |
| CHEMBL3085805 | — | — | 1 | 9.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3087793 | — | Ki | = | 0.04 | nM | 10.40 |
| CHEMBL3087925 | — | Ki | = | 0.042 | nM | 10.38 |
| CHEMBL3087927 | — | Ki | = | 0.043 | nM | 10.37 |
| CHEMBL3086282 | — | Ki | = | 0.051 | nM | 10.29 |
| CHEMBL376756 | KISSPEPTIN-10 | Ki | = | 0.057 | nM | 10.24 |
| CHEMBL3085809 | — | Ki | = | 0.059 | nM | 10.23 |
| CHEMBL2151646 | — | Ki | = | 0.068 | nM | 10.17 |
| CHEMBL3085804 | — | Ki | = | 0.07 | nM | 10.15 |
| CHEMBL3087929 | — | Ki | = | 0.076 | nM | 10.12 |
| CHEMBL2151654 | — | Ki | = | 0.092 | nM | 10.04 |
| CHEMBL3087926 | — | Ki | = | 0.093 | nM | 10.03 |
| CHEMBL3087931 | — | Ki | = | 0.095 | nM | 10.02 |
| CHEMBL3086284 | KISS1-305 | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL2151642 | — | Ki | = | 0.11 | nM | 9.96 |
| CHEMBL3086283 | — | Ki | = | 0.11 | nM | 9.96 |
| CHEMBL2151652 | — | Ki | = | 0.12 | nM | 9.92 |
| CHEMBL2151655 | — | Ki | = | 0.12 | nM | 9.92 |
| CHEMBL3087928 | — | Ki | = | 0.12 | nM | 9.92 |
| CHEMBL3086280 | — | Ki | = | 0.13 | nM | 9.89 |
| CHEMBL3086286 | — | Ki | = | 0.13 | nM | 9.89 |
| CHEMBL3085806 | — | Ki | = | 0.14 | nM | 9.85 |
| CHEMBL3086281 | — | Ki | = | 0.15 | nM | 9.82 |
| CHEMBL3085808 | — | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL3085807 | — | Ki | = | 0.18 | nM | 9.74 |
| CHEMBL3085811 | — | Ki | = | 0.24 | nM | 9.62 |
| CHEMBL3087930 | — | Ki | = | 0.25 | nM | 9.60 |
| CHEMBL3086285 | — | Ki | = | 0.28 | nM | 9.55 |
| CHEMBL3085810 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL3085805 | — | Ki | = | 0.52 | nM | 9.28 |