Assay Detail
Binding
CHEMBL3088740
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Inhibition of ACE (unknown origin) assessed as 3-Hydroxybutyril-glycil-glycil-glycine conversion to 3-hydroxybutyric acid after 60 mins by WST assay
9
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Experimental confirmation of new drug-target interactions predicted by Drug Profile Matching.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.00 | 8.70 |
| Inhibition | 4 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1560 | CAPTOPRIL | 4.0 | 1 | 8.70 |
| CHEMBL1017 | TELMISARTAN | 4.0 | 2 | 5.22 |
| CHEMBL54922 | PROLINE | 2.0 | 2 | 4.07 |
| CHEMBL5416410 | DASATINIB | 4.0 | 2 | - |
| CHEMBL36506 | NOVOBIOCIN | 4.0 | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1560 | CAPTOPRIL | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL1017 | TELMISARTAN | Ki | = | 6000.0 | nM | 5.22 |
| CHEMBL54922 | PROLINE | Ki | = | 86000.0 | nM | 4.07 |
| CHEMBL1017 | TELMISARTAN | Inhibition | - | % | - | |
| CHEMBL5416410 | DASATINIB | Inhibition | - | % | - | |
| CHEMBL36506 | NOVOBIOCIN | Inhibition | - | % | - | |
| CHEMBL54922 | PROLINE | Inhibition | - | % | - | |
| CHEMBL36506 | NOVOBIOCIN | Ki | = | 167000.0 | nM | - |
| CHEMBL5416410 | DASATINIB | Ki | = | 715000.0 | nM | - |