Assay Detail

CHEMBL3089445

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Binding

Agonist activity at S1P3 receptor (unknown origin)

ChEMBL ↗

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Target

Sphingosine 1-phosphate receptor 3 (CHEMBL3892) ↗

Open DB target context

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Sphingosine 1-phosphate receptor 3 (CHEMBL3892) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Sphingosine 1-phosphate receptor 3

CHEMBL3892

Anchored from Assay target.

Protein identity Sphingosine 1-phosphate receptor 3

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Sphingosine 1-phosphate receptor 3 (CHEMBL3892) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Modulators of the Sphingosine 1-phosphate receptor 1.

Urbano M, Guerrero M, Rosen H, Roberts E.
Bioorg Med Chem Lett (2013) 23 : 6377 -6389
PubMed 24125884 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	1	8.52	8.52

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL314854	FINGOLIMOD	4.0	1	8.52

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL314854	FINGOLIMOD	EC50	=	3.0	nM	8.52