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Assay Detail

CHEMBL3089774

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against cell culture derived HCV expressing NS5A-GFP fusion protein infected in human HuH7 cells assessed as inhibition of viral life cycle after 72 hrs by Hoechst-33342 staining-based confocal microscopy
ChEMBL ↗
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Hepacivirus hominis
Cell Type Huh-7
Confidence 1 — Organism
Curated By Autocuration

Target

Hepatitis C virus (CHEMBL379) ↗
Type ORGANISM
Organism Hepacivirus hominis

Publication

Synthesis and evaluation of hexahydropyrimidines and diamines as novel hepatitis C virus inhibitors.
Hwang JY, Kim HY, Jo S, Park E, Choi J, Kong S, Park DS, Heo JM, Lee JS, Ko Y, Choi I, Cechetto J, Kim J, Lee J, No Z, Windisch MP.
Eur J Med Chem (2013) 70 : 315 -325
PubMed 24177358 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 45 5.72 6.50

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL23290 — — 1 6.50
CHEMBL23440 — — 1 6.42
CHEMBL3086935 — — 1 6.21
CHEMBL197209 — — 1 6.19
CHEMBL3086924 — — 1 6.08
CHEMBL3086940 — — 1 6.06
CHEMBL277864 — — 1 6.01
CHEMBL3086941 — — 1 5.96
CHEMBL3086938 — — 1 5.96
CHEMBL3086939 — — 1 5.92
CHEMBL3086925 — — 1 5.89
CHEMBL3086923 — — 1 5.89
CHEMBL3086917 — — 1 5.82
CHEMBL3086920 — — 1 5.82
CHEMBL3086926 — — 1 5.82
CHEMBL1950462 — — 1 5.82
CHEMBL3086918 — — 1 5.80
CHEMBL3086936 — — 1 5.77
CHEMBL3086922 — — 1 5.72
CHEMBL3086921 — — 1 5.72
CHEMBL3085789 — — 1 5.57
CHEMBL3086919 — — 1 5.50
CHEMBL3086914 — — 1 5.43
CHEMBL3086910 — — 1 5.37
CHEMBL1950459 — — 1 5.34
CHEMBL3086927 — — 1 5.33
CHEMBL3086912 — — 1 5.19
CHEMBL3086928 — — 1 4.96
CHEMBL3086942 — — 1 4.96
CHEMBL3086911 — — 1 4.60

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL23290 — EC50 = 320.0 nM 6.50
CHEMBL23440 — EC50 = 380.0 nM 6.42
CHEMBL3086935 — EC50 = 610.0 nM 6.21
CHEMBL197209 — EC50 = 650.0 nM 6.19
CHEMBL3086924 — EC50 = 830.0 nM 6.08
CHEMBL3086940 — EC50 = 880.0 nM 6.06
CHEMBL277864 — EC50 = 980.0 nM 6.01
CHEMBL3086941 — EC50 = 1100.0 nM 5.96
CHEMBL3086938 — EC50 = 1100.0 nM 5.96
CHEMBL3086939 — EC50 = 1200.0 nM 5.92
CHEMBL3086925 — EC50 = 1300.0 nM 5.89
CHEMBL3086923 — EC50 = 1300.0 nM 5.89
CHEMBL1950462 — EC50 = 1500.0 nM 5.82
CHEMBL3086917 — EC50 = 1500.0 nM 5.82
CHEMBL3086920 — EC50 = 1500.0 nM 5.82
CHEMBL3086926 — EC50 = 1500.0 nM 5.82
CHEMBL3086918 — EC50 = 1600.0 nM 5.80
CHEMBL3086936 — EC50 = 1700.0 nM 5.77
CHEMBL3086922 — EC50 = 1900.0 nM 5.72
CHEMBL3086921 — EC50 = 1900.0 nM 5.72
CHEMBL3085789 — EC50 = 2700.0 nM 5.57
CHEMBL3086919 — EC50 = 3200.0 nM 5.50
CHEMBL3086914 — EC50 = 3700.0 nM 5.43
CHEMBL3086910 — EC50 = 4300.0 nM 5.37
CHEMBL1950459 — EC50 = 4600.0 nM 5.34
CHEMBL3086927 — EC50 = 4700.0 nM 5.33
CHEMBL3086912 — EC50 = 6500.0 nM 5.19
CHEMBL3086928 — EC50 = 11000.0 nM 4.96
CHEMBL3086942 — EC50 = 11000.0 nM 4.96
CHEMBL3086911 — EC50 = 25000.0 nM 4.60
CHEMBL1256356 SPERMIDINE TRIHYDROCHLORIDE EC50 > 50000.0 nM -
CHEMBL1528028 PUTRESCINE DIHYDROCHLORIDE EC50 > 50000.0 nM -
CHEMBL3086937 — EC50 > 50000.0 nM -
CHEMBL193646 — EC50 > 50000.0 nM -
CHEMBL3086934 — EC50 > 50000.0 nM -
CHEMBL3086933 — EC50 > 50000.0 nM -
CHEMBL1893630 — EC50 > 50000.0 nM -
CHEMBL3086932 — EC50 > 50000.0 nM -
CHEMBL23194 SPERMINE EC50 > 50000.0 nM -
CHEMBL3086930 — EC50 > 50000.0 nM -
CHEMBL3086929 — EC50 > 50000.0 nM -
CHEMBL3086913 — EC50 > 50000.0 nM -
CHEMBL3086931 — EC50 > 50000.0 nM -
CHEMBL3086915 — EC50 > 50000.0 nM -
CHEMBL3086916 — EC50 > 50000.0 nM -