Assay Detail
Functional
CHEMBL3089823
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV2 ROD infected in human CEM cells assessed as virus-induced giant cell formation after 4 days by microscopic analysis
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 2 |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 2 (CHEMBL380) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 2 |
Publication
Design, synthesis and biological evaluation of phosphorodiamidate prodrugs of antiviral and anticancer nucleosides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 6.40 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3086959 | — | — | 1 | 7.89 |
| CHEMBL3086958 | — | — | 1 | 7.52 |
| CHEMBL3086947 | — | — | 1 | 7.31 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 7.17 |
| CHEMBL3086944 | — | — | 1 | 7.02 |
| CHEMBL3086946 | — | — | 1 | 6.85 |
| CHEMBL141 | LAMIVUDINE | 4.0 | 1 | 6.75 |
| CHEMBL3086945 | — | — | 1 | 6.42 |
| CHEMBL3086950 | — | — | 1 | 6.40 |
| CHEMBL991 | STAVUDINE | 4.0 | 1 | 6.24 |
| CHEMBL3086953 | — | — | 1 | 5.96 |
| CHEMBL3086954 | — | — | 1 | 5.92 |
| CHEMBL23094 | — | — | 1 | 5.55 |
| CHEMBL1380 | ABACAVIR | 4.0 | 1 | 4.75 |
| CHEMBL3086949 | — | — | 1 | 4.24 |
| CHEMBL3086952 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3086959 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3086958 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3086947 | — | EC50 | = | 49.0 | nM | 7.31 |
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 67.0 | nM | 7.17 |
| CHEMBL3086944 | — | EC50 | = | 96.0 | nM | 7.02 |
| CHEMBL3086946 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL141 | LAMIVUDINE | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL3086945 | — | EC50 | = | 380.0 | nM | 6.42 |
| CHEMBL3086950 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL991 | STAVUDINE | EC50 | = | 580.0 | nM | 6.24 |
| CHEMBL3086953 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3086954 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL23094 | — | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL1380 | ABACAVIR | EC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL3086949 | — | EC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL3086952 | — | EC50 | > | 50000.0 | nM | - |