Assay Detail
Binding
CHEMBL3090352
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Inhibition of GST-tagged recombinant human PTP1B
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of novel PTP1B inhibitors via pharmacophore-oriented scaffold hopping from Ertiprotafib.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.17 | 6.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL324232 | — | — | 1 | 6.06 |
| CHEMBL3088252 | — | — | 1 | 5.89 |
| CHEMBL3088258 | — | — | 1 | 5.41 |
| CHEMBL3088269 | — | — | 1 | 5.00 |
| CHEMBL3088268 | — | — | 1 | 4.99 |
| CHEMBL3088264 | — | — | 1 | 4.98 |
| CHEMBL3088256 | — | — | 1 | 4.62 |
| CHEMBL3088263 | — | — | 1 | 4.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL324232 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL3088252 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL3088258 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL3088269 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3088268 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL3088264 | — | IC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL3088256 | — | IC50 | = | 23900.0 | nM | 4.62 |
| CHEMBL3088263 | — | IC50 | = | 40300.0 | nM | 4.39 |