Assay Detail
Binding
CHEMBL3090684
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Inhibition of PTP1B (unknown origin) assessed as p-nitrophenol release from pNPP substrate after 30 mins by spectrophotometry
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Protein tyrosine phosphatase 1B (PTP1B) inhibitors from Morinda citrifolia (Noni) and their insulin mimetic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 4.85 | 5.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL169 | URSOLIC ACID | 2.0 | 1 | 5.38 |
| CHEMBL361362 | SYRINGARESINOL | — | 1 | 4.82 |
| CHEMBL454592 | — | — | 1 | 4.77 |
| CHEMBL460862 | (-)-PINORESINOL | — | 1 | 4.73 |
| CHEMBL3088130 | — | — | 1 | 4.71 |
| CHEMBL1688937 | — | — | 1 | 4.66 |
| CHEMBL3088126 | — | — | 1 | - |
| CHEMBL3088127 | — | — | 1 | - |
| CHEMBL3088128 | — | — | 1 | - |
| CHEMBL3088129 | — | — | 1 | - |
| CHEMBL3088131 | — | — | 1 | - |
| CHEMBL482240 | AMERICANIN A | — | 1 | - |
| CHEMBL227187 | — | — | 1 | - |
| CHEMBL3088132 | — | — | 1 | - |
| CHEMBL3088133 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL169 | URSOLIC ACID | IC50 | = | 4120.0 | nM | 5.38 |
| CHEMBL361362 | SYRINGARESINOL | IC50 | = | 15010.0 | nM | 4.82 |
| CHEMBL454592 | — | IC50 | = | 16820.0 | nM | 4.77 |
| CHEMBL460862 | (-)-PINORESINOL | IC50 | = | 18690.0 | nM | 4.73 |
| CHEMBL3088130 | — | IC50 | = | 19560.0 | nM | 4.71 |
| CHEMBL1688937 | — | IC50 | = | 21860.0 | nM | 4.66 |
| CHEMBL3088126 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3088127 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3088128 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3088129 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3088131 | — | IC50 | - | — | - | |
| CHEMBL482240 | AMERICANIN A | IC50 | - | — | - | |
| CHEMBL227187 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3088132 | — | IC50 | - | — | - | |
| CHEMBL3088133 | — | IC50 | - | — | - |