Assay Detail
Functional
CHEMBL3090686
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Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced NO production incubated 30 mins prior to LPS-challenge measured after 24 hrs by Griess assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BV-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Bioactive lignans from the trunk of Abies holophylla.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.49 | 4.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL463246 | ALPHA-CONIDENDRIN | — | 1 | 4.54 |
| CHEMBL3088134 | — | — | 1 | 4.51 |
| CHEMBL3088137 | — | — | 1 | 4.48 |
| CHEMBL3088138 | — | — | 1 | 4.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL463246 | ALPHA-CONIDENDRIN | IC50 | = | 28500.0 | nM | 4.54 |
| CHEMBL3088134 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL3088137 | — | IC50 | = | 32900.0 | nM | 4.48 |
| CHEMBL3088138 | — | IC50 | = | 36400.0 | nM | 4.44 |