Assay Detail
Functional
CHEMBL3090800
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Growth inhibition of rat C6 cells after 24 hrs by trypan blue-based cell counting method
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | C6 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Improved synthesis and in vitro evaluation of the cytotoxic profile of oxysterols oxidized at C4 (4α- and 4β-hydroxycholesterol) and C7 (7-ketocholesterol, 7α- and 7β-hydroxycholesterol) on cells of the central nervous system.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.64 | 4.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL497834 | — | — | 1 | 4.82 |
| CHEMBL1278177 | 7-OXOCHOLESTEROL | — | 1 | 4.70 |
| CHEMBL497207 | — | — | 1 | 4.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL497834 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL1278177 | 7-OXOCHOLESTEROL | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL497207 | — | IC50 | = | 40000.0 | nM | 4.40 |