Assay Detail
ADMET
CHEMBL3090802
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Growth inhibition of mouse 158N cells after 24 hrs by trypan blue-based cell counting method
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Mus musculus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Improved synthesis and in vitro evaluation of the cytotoxic profile of oxysterols oxidized at C4 (4α- and 4β-hydroxycholesterol) and C7 (7-ketocholesterol, 7α- and 7β-hydroxycholesterol) on cells of the central nervous system.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.88 | 5.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1278177 | 7-OXOCHOLESTEROL | — | 1 | 5.00 |
| CHEMBL497207 | — | — | 1 | 4.82 |
| CHEMBL497834 | — | — | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1278177 | 7-OXOCHOLESTEROL | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL497207 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL497834 | — | IC50 | = | 15000.0 | nM | 4.82 |