Assay Detail

CHEMBL3090814

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Functional

Antiproliferative activity against human MOLM13 cells containing MLL-AF9

ChEMBL ↗

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Target

MOLM-13 (CHEMBL3706572) ↗

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MOLM-13 (CHEMBL3706572) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target MOLM-13

CHEMBL3706572

Anchored from Assay target.

Protein identity MOLM-13

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	MOLM-13
Confidence	1 — Organism
Curated By	Autocuration

Target

MOLM-13 (CHEMBL3706572) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

A medicinal chemistry perspective for targeting histone H3 lysine-79 methyltransferase DOT1L.

Anglin JL, Song Y.
J Med Chem (2013) 56 : 8972 -8983
PubMed 23879463 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	3	8.40	8.40

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL3414626	PINOMETOSTAT	2.0	1	8.40
CHEMBL2169919	—	—	1	8.40
CHEMBL2171169	—	—	1	8.40

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL3414626	PINOMETOSTAT	EC50	=	4.0	nM	8.40
CHEMBL2169919	—	EC50	=	4.0	nM	8.40
CHEMBL2171169	—	EC50	=	4.0	nM	8.40