Assay Detail
Binding
CHEMBL3090823
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Competitive inhibition of recombinant human DOT1L using adenosine/deazaadenosine as substrate and SAM cofactor
31
Total Activities
31
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Histone-lysine N-methyltransferase, H3 lysine-79 specific (CHEMBL1795117) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
A medicinal chemistry perspective for targeting histone H3 lysine-79 methyltransferase DOT1L.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 25 | 6.25 | 9.30 |
| IC50 | 6 | 6.75 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3087498 | — | — | 1 | 9.52 |
| CHEMBL2171169 | — | — | 1 | 9.30 |
| CHEMBL2171170 | — | — | 1 | 9.10 |
| CHEMBL3087503 | — | — | 1 | 8.96 |
| CHEMBL3087502 | — | — | 1 | 8.89 |
| CHEMBL3087500 | — | — | 1 | 7.89 |
| CHEMBL3087638 | — | — | 1 | 7.42 |
| CHEMBL2170997 | — | — | 1 | 7.24 |
| CHEMBL3087504 | — | — | 1 | 7.16 |
| CHEMBL2349526 | — | — | 1 | 7.11 |
| CHEMBL2170994 | — | — | 1 | 7.09 |
| CHEMBL2172427 | — | — | 1 | 6.92 |
| CHEMBL418052 | S-ADENOSYLHOMOCYSTEINE | — | 1 | 6.80 |
| CHEMBL2170989 | — | — | 1 | 6.26 |
| CHEMBL2170991 | — | — | 1 | 5.96 |
| CHEMBL2171174 | — | — | 1 | 5.96 |
| CHEMBL2170985 | — | — | 1 | 5.72 |
| CHEMBL3087639 | — | — | 1 | 4.92 |
| CHEMBL3087637 | — | — | 1 | 4.80 |
| CHEMBL2170984 | — | — | 1 | 4.80 |
| CHEMBL99203 | IODOTUBERCIDIN | — | 1 | 4.75 |
| CHEMBL2170990 | — | — | 1 | 4.75 |
| CHEMBL3087636 | — | — | 1 | 4.70 |
| CHEMBL2170979 | — | — | 1 | 4.66 |
| CHEMBL2170983 | — | — | 1 | 4.66 |
| CHEMBL472733 | — | — | 1 | 4.42 |
| CHEMBL2170976 | — | — | 1 | 4.34 |
| CHEMBL538693 | — | — | 1 | 4.00 |
| CHEMBL2169919 | — | — | 1 | - |
| CHEMBL3087501 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3087498 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL2171169 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL2171170 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL3087503 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL3087502 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL3087500 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL3087638 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL2170997 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL3087504 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL2349526 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL2170994 | — | Ki | = | 82.0 | nM | 7.09 |
| CHEMBL2172427 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL418052 | S-ADENOSYLHOMOCYSTEINE | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL2170989 | — | Ki | = | 550.0 | nM | 6.26 |
| CHEMBL2170991 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL2171174 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL2170985 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL3087639 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL3087637 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL2170984 | — | Ki | = | 16000.0 | nM | 4.80 |
| CHEMBL99203 | IODOTUBERCIDIN | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL2170990 | — | Ki | = | 18000.0 | nM | 4.75 |
| CHEMBL3087636 | — | Ki | = | 20000.0 | nM | 4.70 |
| CHEMBL2170979 | — | Ki | = | 22000.0 | nM | 4.66 |
| CHEMBL2170983 | — | Ki | = | 22000.0 | nM | 4.66 |
| CHEMBL472733 | — | Ki | = | 38000.0 | nM | 4.42 |
| CHEMBL2170976 | — | Ki | = | 46000.0 | nM | 4.34 |
| CHEMBL538693 | — | Ki | = | 100000.0 | nM | 4.00 |
| CHEMBL2169919 | — | Ki | = | 0.3 | nM | - |
| CHEMBL3087501 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL3414626 | PINOMETOSTAT | Ki | < | 0.07 | nM | - |