Assay Detail
Functional
CHEMBL3090922
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Growth inhibition of human HCT116 cells after 96 hrs by CCK-8 assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
The sulfamide moiety affords higher inhibitory activity and oral bioavailability to a series of coumarin dual selective RAF/MEK inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 7.13 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3086065 | — | — | 1 | 8.40 |
| CHEMBL3086078 | — | — | 1 | 8.10 |
| CHEMBL3086066 | — | — | 1 | 7.92 |
| CHEMBL3086073 | — | — | 1 | 7.64 |
| CHEMBL3086068 | — | — | 1 | 7.52 |
| CHEMBL3086075 | — | — | 1 | 7.44 |
| CHEMBL3086069 | — | — | 1 | 7.44 |
| CHEMBL3086064 | — | — | 1 | 7.41 |
| CHEMBL3086074 | — | — | 1 | 7.38 |
| CHEMBL3086071 | — | — | 1 | 7.17 |
| CHEMBL3086072 | — | — | 1 | 7.03 |
| CHEMBL3086076 | — | — | 1 | 6.80 |
| CHEMBL3086070 | — | — | 1 | 6.77 |
| CHEMBL3086063 | — | — | 1 | 6.54 |
| CHEMBL81277 | — | — | 1 | 6.44 |
| CHEMBL3086062 | — | — | 1 | 5.92 |
| CHEMBL3086067 | — | — | 1 | 5.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3086065 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3086078 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3086066 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL3086073 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL3086068 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3086075 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL3086069 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL3086064 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL3086074 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL3086071 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL3086072 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL3086076 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL3086070 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL3086063 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL81277 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL3086062 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL3086067 | — | IC50 | = | 4600.0 | nM | 5.34 |