Assay Detail
Binding
CHEMBL3090997
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Inhibition of Influenza A virus M2 ion channel by two-electrode voltage clamp assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
3-Azatetracyclo[5.2.1.1(5,8).0(1,5)]undecane derivatives: from wild-type inhibitors of the M2 ion channel of influenza A virus to derivatives with potent activity against the V27A mutant.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.68 | 4.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1774312 | — | — | 1 | 4.90 |
| CHEMBL3088158 | — | — | 1 | 4.85 |
| CHEMBL3088159 | — | — | 1 | 4.72 |
| CHEMBL2324172 | — | — | 1 | 4.23 |
| CHEMBL3088160 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1774312 | — | IC50 | = | 12600.0 | nM | 4.90 |
| CHEMBL3088158 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL3088159 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL2324172 | — | IC50 | = | 59000.0 | nM | 4.23 |
| CHEMBL3088160 | — | IC50 | > | 100000.0 | nM | - |