Assay Detail
Binding
CHEMBL3091212
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Wistar rat testicular C17,20-lyase using [3H]17-hydroxyprogesterone as substrate preincubated for 20 mins
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Steroid 17-alpha-hydroxylase/17,20 lyase (CHEMBL4430) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
An efficient approach to novel 17-5'-(1',2',4')-oxadiazolyl androstenes via the cyclodehydration of cytotoxic O-steroidacylamidoximes, and an evaluation of their inhibitory action on 17α-hydroxylase/C₁₇,₂₀-lyase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.87 | 7.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL254328 | ABIRATERONE | 3.0 | 1 | 7.90 |
| CHEMBL157101 | KETOCONAZOLE | 4.0 | 1 | 6.50 |
| CHEMBL3087962 | — | — | 1 | 6.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL254328 | ABIRATERONE | IC50 | = | 12.5 | nM | 7.90 |
| CHEMBL157101 | KETOCONAZOLE | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL3087962 | — | IC50 | = | 600.0 | nM | 6.22 |