Assay Detail
Binding
CHEMBL3094808
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Inhibition of human erythrocytic AChE using acetylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition measured every 1 min by Ellman method
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibition of cholinesterase and monoamine oxidase-B activity by Tacrine-Homoisoflavonoid hybrids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.85 | 7.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3093173 | — | — | 1 | 7.01 |
| CHEMBL3093180 | — | — | 1 | 6.98 |
| CHEMBL3093175 | — | — | 1 | 6.92 |
| CHEMBL3093174 | — | — | 1 | 6.80 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 6.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3093173 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL3093180 | — | IC50 | = | 105.3 | nM | 6.98 |
| CHEMBL3093175 | — | IC50 | = | 121.6 | nM | 6.92 |
| CHEMBL3093174 | — | IC50 | = | 156.8 | nM | 6.80 |
| CHEMBL95 | TACRINE | IC50 | = | 285.0 | nM | 6.54 |