Assay Detail
Binding
CHEMBL3095035
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Uncompetitive inhibition of porcine kidney TNAP assessed as para nitrophenylphosphate conversion to p-nitrophenolate at pH 7.8 by Michaelis-Menten plot analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Tissue | Kidney |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Inhibitors of tissue-nonspecific alkaline phosphatase: design, synthesis, kinetics, biomineralization and cellular tests.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 5.22 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3092293 | — | — | 1 | 5.89 |
| CHEMBL3092295 | — | — | 1 | 5.41 |
| CHEMBL3092296 | — | — | 1 | 5.30 |
| CHEMBL3092294 | — | — | 1 | 4.99 |
| CHEMBL1454 | LEVAMISOLE | 4.0 | 1 | 4.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3092293 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL3092295 | — | Ki | = | 3900.0 | nM | 5.41 |
| CHEMBL3092296 | — | Ki | = | 5000.0 | nM | 5.30 |
| CHEMBL3092294 | — | Ki | = | 10300.0 | nM | 4.99 |
| CHEMBL1454 | LEVAMISOLE | Ki | = | 30500.0 | nM | 4.52 |