Compound Detail
CHEMBL1454
LEVAMISOLE 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL1454 |
| Name | LEVAMISOLE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | HLFSDGLLUJUHTE-SNVBAGLBSA-N |
| Therapeutic | ✓ Yes |
7
Targets
27
Activities
3
Assay Types
30
PK Parameters
20
Publications
4
Known Names
5
Indications
Molecular Properties
204.3
MW (Da)
2.15
ALogP
3
HBA
0
HBD
15.6
PSA (Ų)
0.70
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1990 |
| Availability | Withdrawn |
| Chirality | Single Enantiomer |
Indications
Helminthiasis Carcinoma, Hepatocellular Severe Acute Respiratory Syndrome Acne Vulgaris Anemia, Aplastic
ATC Classification
P02CE01
levamisole
Level 1: ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
Level 2: ANTHELMINTICS
Drug Warnings
Withdrawn
neurotoxicity
Adverse effects that cause encephalitis and mortality
Withdrawn
neurotoxicity
leukoencephalopathy
Withdrawn
General Warning
Adverse effects that cause encephalitis and mortality
Withdrawn
immune system toxicity
Adverse effects that cause encephalitis and mortality
Activity Summary
IC50 17 meas. best 5.36
Ki 7 meas. best 5.74
EC50 3 meas. best 6.68
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Nippostrongylus brasiliensis CHEMBL613822 | EC50 | 6.68 | 6.68 | 210.0 | 1 |
| Alkaline phosphatase, tissue-nonspecific isozyme CHEMBL2406894 | Ki | 5.74 | 5.74 | 1810.0 | 1 |
| Unchecked CHEMBL612545 | Ki | 5.57 | 4.6125 | 2703.0 | 4 |
| Unchecked CHEMBL612545 | IC50 | 5.36 | 4.6967 | 4392.0 | 6 |
| Haemonchus contortus CHEMBL613144 | EC50 | 4.82 | 4.785 | 15000.0 | 2 |
| Alkaline phosphatase, tissue-nonspecific isozyme CHEMBL5979 | Ki | 4.8 | 4.8 | 16000.0 | 1 |
| Alkaline phosphatase, tissue-nonspecific isozyme CHEMBL2406894 | IC50 | 4.72 | 4.72 | 19210.0 | 3 |
| Alkaline phosphatase, tissue-nonspecific isozyme CHEMBL5979 | IC50 | 4.72 | 4.7033 | 19200.0 | 3 |
| Intestinal-type alkaline phosphatase CHEMBL5573 | IC50 | 4.69 | 4.69 | 20210.0 | 1 |
| NON-PROTEIN TARGET CHEMBL3879801 | IC50 | 4.02 | 4.02 | 96000.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| AUC | 8940.0 | ng.hr.mL-1 | Canis lupus familiaris |
| AUC | 12200.0 | ng.hr.mL-1 | Canis lupus familiaris |
| AUC | 18100.0 | ng.hr.mL-1 | Canis lupus familiaris |
| AUC | 3070.0 | ng.hr.mL-1 | Homo sapiens |
| AUC | 3070.0 | ng.hr.mL-1 | Homo sapiens |
| AUC | 3070.0 | ng.hr.mL-1 | Homo sapiens |
| CL | 8.92 | mL.min-1.kg-1 | Canis lupus familiaris |
| CL | 7.56 | mL.min-1.kg-1 | Homo sapiens |
| CL | 8.25 | mL.min-1.kg-1 | Homo sapiens |
| CL | 8.04 | mL.min-1.kg-1 | Homo sapiens |
| CL | 1.5 | L/hr | Homo sapiens |
| CL | 1.86 | L/hr | Homo sapiens |
| CL | 1.75 | L/hr | Homo sapiens |
| Cmax | 9691.63 | nM | Canis lupus familiaris |
| Cmax | 16299.56 | nM | Canis lupus familiaris |
| Cmax | 4013.71 | nM | Homo sapiens |
| Cmax | 3289.28 | nM | Homo sapiens |
| Cmax | 3509.54 | nM | Homo sapiens |
| F | 44.0 | % | Canis lupus familiaris |
| F | 64.0 | % | Canis lupus familiaris |
| F | 64.7 | % | Homo sapiens |
| F | 61.5 | % | Homo sapiens |
| F | 62.5 | % | Homo sapiens |
| T1/2 | 5.6 | hr | Homo sapiens |
| T1/2 | 6.0 | hr | Not specified |
| T1/2 | 1.6 | hr | Canis lupus familiaris |
| T1/2 | 1.3 | hr | Canis lupus familiaris |
| T1/2 | 1.8 | hr | Canis lupus familiaris |
| T1/2 | 5.9 | hr | Homo sapiens |
| T1/2 | 5.4 | hr | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine