Assay Detail
Binding
CHEMBL3776497
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Inhibition of porcine kidney TNAP using para-nitrophenylphosphate as substrate preincubated for 10 mins at pH 7.8 followed by substrate addition
8
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis of benzofuran derivatives as selective inhibitors of tissue-nonspecific alkaline phosphatase: effects on cell toxicity and osteoblast-induced mineralization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 4.42 | 4.50 |
| IC50 | 4 | 4.47 | 4.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3774470 | — | — | 2 | 4.55 |
| CHEMBL1454 | LEVAMISOLE | 4.0 | 2 | 4.39 |
| CHEMBL3774946 | — | — | 2 | - |
| CHEMBL3774723 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3774470 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL3774470 | — | Ki | = | 32000.0 | nM | 4.50 |
| CHEMBL1454 | LEVAMISOLE | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL1454 | LEVAMISOLE | Ki | = | 47000.0 | nM | 4.33 |
| CHEMBL3774946 | — | Ki | - | — | - | |
| CHEMBL3774723 | — | Ki | - | — | - | |
| CHEMBL3774723 | — | IC50 | > | 400000.0 | nM | - |
| CHEMBL3774946 | — | IC50 | > | 400000.0 | nM | - |