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Assay Detail

CHEMBL834150

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Functional
In vitro anthelmintic activity against Haemonchus contortus after 24 hr of incubation using larval mobility assay
18
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Haemonchus contortus
Confidence 1 — Organism
Curated By Intermediate

Target

Haemonchus contortus (CHEMBL613144)
Type ORGANISM
Organism Haemonchus contortus

Publication

Novel thiophenes and analogues with anthelmintic activity against Haemonchus contortus.
González IC, Davis LN, Smith CK.
Bioorg Med Chem Lett (2004) 14 : 4037 -4043
PubMed 15225722 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 18 4.50 5.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL366125 1 5.22
CHEMBL369739 1 4.92
CHEMBL181438 1 4.82
CHEMBL1454 LEVAMISOLE 4.0 1 4.82
CHEMBL182609 1 4.77
CHEMBL182920 1 4.55
CHEMBL361234 1 4.50
CHEMBL181489 1 4.48
CHEMBL182760 1 4.19
CHEMBL180141 1 4.19
CHEMBL182876 2 4.17
CHEMBL433941 1 4.10
CHEMBL183075 1 4.10
CHEMBL362183 1 -
CHEMBL184966 1 -
CHEMBL369767 1 -
CHEMBL367370 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL366125 EC50 = 6000.0 nM 5.22
CHEMBL369739 EC50 = 12000.0 nM 4.92
CHEMBL181438 EC50 = 15000.0 nM 4.82
CHEMBL1454 LEVAMISOLE EC50 = 15000.0 nM 4.82
CHEMBL182609 EC50 = 17000.0 nM 4.77
CHEMBL182920 EC50 = 28000.0 nM 4.55
CHEMBL361234 EC50 = 32000.0 nM 4.50
CHEMBL181489 EC50 = 33000.0 nM 4.48
CHEMBL182760 EC50 = 64000.0 nM 4.19
CHEMBL180141 EC50 = 65000.0 nM 4.19
CHEMBL182876 EC50 = 68000.0 nM 4.17
CHEMBL182876 EC50 = 68000.0 nM 4.17
CHEMBL183075 EC50 = 80000.0 nM 4.10
CHEMBL433941 EC50 = 80000.0 nM 4.10
CHEMBL367370 EC50 = 175000.0 nM -
CHEMBL369767 EC50 = 102000.0 nM -
CHEMBL362183 EC50 = 190000.0 nM -
CHEMBL184966 EC50 = 161000.0 nM -