Assay Detail
Binding
CHEMBL5537008
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of bovine TNAP using CDP-star as substrate preincubated with enzyme for 3 to 5 mins followed by substrate addition and measured after 15 mins by luminescence based analysis
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Alkaline phosphatase, tissue-nonspecific isozyme (CHEMBL2406894) ↗| Type | SINGLE PROTEIN |
| Organism | Bos taurus |
Publication
Unveiling sultam in drug discovery: spotlight on the underexplored scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.24 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5595268 | — | — | 1 | 6.96 |
| CHEMBL5562714 | — | — | 1 | 6.72 |
| CHEMBL5565700 | — | — | 1 | 6.70 |
| CHEMBL5573727 | — | — | 1 | 6.57 |
| CHEMBL5591314 | — | — | 1 | 6.57 |
| CHEMBL5562682 | — | — | 1 | 6.52 |
| CHEMBL5571035 | — | — | 1 | 6.51 |
| CHEMBL5591499 | — | — | 1 | 6.38 |
| CHEMBL5562695 | — | — | 1 | 6.36 |
| CHEMBL5583594 | — | — | 1 | 6.34 |
| CHEMBL5569727 | — | — | 1 | 6.30 |
| CHEMBL5591327 | — | — | 1 | 5.92 |
| CHEMBL5566772 | — | — | 1 | 5.84 |
| CHEMBL5573339 | — | — | 1 | 5.18 |
| CHEMBL1454 | LEVAMISOLE | 4.0 | 1 | 4.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5595268 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL5562714 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL5565700 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL5573727 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL5591314 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL5562682 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL5571035 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL5591499 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL5562695 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL5583594 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL5569727 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL5591327 | — | IC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL5566772 | — | IC50 | = | 1450.0 | nM | 5.84 |
| CHEMBL5573339 | — | IC50 | = | 6630.0 | nM | 5.18 |
| CHEMBL1454 | LEVAMISOLE | IC50 | = | 19210.0 | nM | 4.72 |