Assay Detail
Binding
CHEMBL4273104
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Inhibition of human TNAP expressed in COS7 cells using CDP-star as substrate preincubated for 5 to 10 mins followed by substrate addition measured after 20 mins by luminescence-based assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Alkaline phosphatase, tissue-nonspecific isozyme (CHEMBL5979) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Exploration of carboxy pyrazole derivatives: Synthesis, alkaline phosphatase, nucleotide pyrophosphatase/phosphodiesterase and nucleoside triphosphate diphosphohydrolase inhibition studies with potential anticancer profile.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 5.18 | 6.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL243638 | — | — | 1 | 6.04 |
| CHEMBL4293491 | — | — | 1 | 5.97 |
| CHEMBL4279910 | — | — | 1 | 5.82 |
| CHEMBL4295005 | — | — | 1 | 5.59 |
| CHEMBL4283075 | — | — | 1 | 5.45 |
| CHEMBL4286443 | — | — | 1 | 5.34 |
| CHEMBL4283786 | — | — | 1 | 5.31 |
| CHEMBL4280333 | — | — | 1 | 5.26 |
| CHEMBL4288229 | — | — | 1 | 5.24 |
| CHEMBL390695 | — | — | 1 | 5.24 |
| CHEMBL4284994 | — | — | 1 | 5.21 |
| CHEMBL298036 | — | — | 1 | 5.19 |
| CHEMBL4287085 | — | — | 1 | 5.11 |
| CHEMBL4290501 | — | — | 1 | 5.08 |
| CHEMBL4291645 | — | — | 1 | 4.95 |
| CHEMBL4291589 | — | — | 1 | 4.88 |
| CHEMBL4280275 | — | — | 1 | 4.75 |
| CHEMBL4288181 | — | — | 1 | 4.72 |
| CHEMBL1454 | LEVAMISOLE | 4.0 | 1 | 4.69 |
| CHEMBL4285649 | — | — | 1 | 4.58 |
| CHEMBL4283728 | — | — | 1 | 4.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL243638 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL4293491 | — | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL4279910 | — | IC50 | = | 1510.0 | nM | 5.82 |
| CHEMBL4295005 | — | IC50 | = | 2590.0 | nM | 5.59 |
| CHEMBL4283075 | — | IC50 | = | 3580.0 | nM | 5.45 |
| CHEMBL4286443 | — | IC50 | = | 4580.0 | nM | 5.34 |
| CHEMBL4283786 | — | IC50 | = | 4910.0 | nM | 5.31 |
| CHEMBL4280333 | — | IC50 | = | 5430.0 | nM | 5.26 |
| CHEMBL4288229 | — | IC50 | = | 5780.0 | nM | 5.24 |
| CHEMBL390695 | — | IC50 | = | 5710.0 | nM | 5.24 |
| CHEMBL4284994 | — | IC50 | = | 6140.0 | nM | 5.21 |
| CHEMBL298036 | — | IC50 | = | 6510.0 | nM | 5.19 |
| CHEMBL4287085 | — | IC50 | = | 7860.0 | nM | 5.11 |
| CHEMBL4290501 | — | IC50 | = | 8240.0 | nM | 5.08 |
| CHEMBL4291645 | — | IC50 | = | 11120.0 | nM | 4.95 |
| CHEMBL4291589 | — | IC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL4280275 | — | IC50 | = | 17700.0 | nM | 4.75 |
| CHEMBL4288181 | — | IC50 | = | 19100.0 | nM | 4.72 |
| CHEMBL1454 | LEVAMISOLE | IC50 | = | 20210.0 | nM | 4.69 |
| CHEMBL4285649 | — | IC50 | = | 26400.0 | nM | 4.58 |
| CHEMBL4283728 | — | IC50 | = | 42000.0 | nM | 4.38 |