Assay Detail
Binding
CHEMBL3404590
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of bovine kidney non-specific alkaline phosphatase using CDP-star chemiluminescent substrate assessed as change in luminescence by spectrophotometric method
38
Total Activities
19
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Alkaline phosphatase, tissue-nonspecific isozyme (CHEMBL2406894) ↗| Type | SINGLE PROTEIN |
| Organism | Bos taurus |
Publication
Diarylsulfonamides and their bioisosteres as dual inhibitors of alkaline phosphatase and carbonic anhydrase: Structure activity relationship and molecular modelling studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.43 | 6.94 |
| Ki | 19 | 5.79 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3403324 | — | — | 2 | 7.30 |
| CHEMBL3403327 | — | — | 2 | 7.22 |
| CHEMBL182659 | — | — | 2 | 7.16 |
| CHEMBL3403329 | — | — | 2 | 6.89 |
| CHEMBL3403320 | — | — | 2 | 6.52 |
| CHEMBL3403317 | — | — | 2 | 6.04 |
| CHEMBL3403325 | — | — | 2 | 6.02 |
| CHEMBL511186 | — | — | 2 | 5.90 |
| CHEMBL23922 | — | — | 2 | 5.86 |
| CHEMBL1454 | LEVAMISOLE | 4.0 | 2 | 5.74 |
| CHEMBL3403318 | — | — | 2 | 5.40 |
| CHEMBL3403321 | — | — | 2 | 5.35 |
| CHEMBL3403322 | — | — | 2 | 4.79 |
| CHEMBL23559 | — | — | 2 | 4.78 |
| CHEMBL1607835 | — | — | 2 | 4.75 |
| CHEMBL3403319 | — | — | 2 | 4.60 |
| CHEMBL3403323 | — | — | 2 | 4.04 |
| CHEMBL3403326 | — | — | 2 | - |
| CHEMBL3403328 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3403324 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL3403327 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL182659 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL3403324 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL3403329 | — | Ki | = | 128.0 | nM | 6.89 |
| CHEMBL3403327 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL182659 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL3403320 | — | Ki | = | 299.0 | nM | 6.52 |
| CHEMBL3403329 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL3403320 | — | IC50 | = | 613.0 | nM | 6.21 |
| CHEMBL3403317 | — | Ki | = | 918.0 | nM | 6.04 |
| CHEMBL3403325 | — | Ki | = | 950.0 | nM | 6.02 |
| CHEMBL511186 | — | Ki | = | 1250.0 | nM | 5.90 |
| CHEMBL23922 | — | Ki | = | 1390.0 | nM | 5.86 |
| CHEMBL1454 | LEVAMISOLE | Ki | = | 1810.0 | nM | 5.74 |
| CHEMBL3403325 | — | IC50 | = | 2240.0 | nM | 5.65 |
| CHEMBL3403317 | — | IC50 | = | 2870.0 | nM | 5.54 |
| CHEMBL511186 | — | IC50 | = | 2940.0 | nM | 5.53 |
| CHEMBL23922 | — | IC50 | = | 3260.0 | nM | 5.49 |
| CHEMBL3403318 | — | Ki | = | 3960.0 | nM | 5.40 |
| CHEMBL3403321 | — | Ki | = | 4510.0 | nM | 5.35 |
| CHEMBL3403318 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL3403322 | — | Ki | = | 16200.0 | nM | 4.79 |
| CHEMBL23559 | — | Ki | = | 16610.0 | nM | 4.78 |
| CHEMBL1607835 | — | Ki | = | 17590.0 | nM | 4.75 |
| CHEMBL1454 | LEVAMISOLE | IC50 | = | 19210.0 | nM | 4.72 |
| CHEMBL3403321 | — | IC50 | = | 22500.0 | nM | 4.65 |
| CHEMBL3403319 | — | Ki | = | 25100.0 | nM | 4.60 |
| CHEMBL1607835 | — | IC50 | = | 41200.0 | nM | 4.38 |
| CHEMBL3403322 | — | IC50 | = | 55600.0 | nM | 4.25 |
| CHEMBL3403319 | — | IC50 | = | 58600.0 | nM | 4.23 |
| CHEMBL23559 | — | IC50 | = | 70100.0 | nM | 4.15 |
| CHEMBL3403323 | — | Ki | = | 91870.0 | nM | 4.04 |
| CHEMBL3403326 | — | IC50 | - | — | - | |
| CHEMBL3403323 | — | IC50 | = | 221900.0 | nM | - |
| CHEMBL3403326 | — | Ki | - | — | - | |
| CHEMBL3403328 | — | Ki | - | — | - | |
| CHEMBL3403328 | — | IC50 | - | — | - |