Assay Detail
Binding
CHEMBL1014656
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Inhibition of TNSALP
31
Total Activities
31
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Alkaline phosphatase, tissue-nonspecific isozyme (CHEMBL5979) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design and synthesis of pyrazole derivatives as potent and selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 6.76 | 8.30 |
| Ki | 2 | 4.45 | 4.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL461194 | — | — | 1 | 8.30 |
| CHEMBL450981 | — | — | 1 | 7.51 |
| CHEMBL512931 | — | — | 1 | 7.46 |
| CHEMBL466808 | — | — | 1 | 7.46 |
| CHEMBL467008 | — | — | 1 | 7.36 |
| CHEMBL467854 | — | — | 1 | 7.36 |
| CHEMBL466809 | — | — | 1 | 7.34 |
| CHEMBL459706 | — | — | 1 | 7.33 |
| CHEMBL445965 | — | — | 1 | 7.29 |
| CHEMBL511689 | — | — | 1 | 7.25 |
| CHEMBL459707 | — | — | 1 | 7.09 |
| CHEMBL501296 | — | — | 1 | 7.00 |
| CHEMBL466992 | — | — | 1 | 6.92 |
| CHEMBL459709 | — | — | 1 | 6.90 |
| CHEMBL461425 | — | — | 1 | 6.87 |
| CHEMBL459708 | — | — | 1 | 6.54 |
| CHEMBL502169 | — | — | 1 | 6.49 |
| CHEMBL445266 | — | — | 1 | 6.43 |
| CHEMBL509575 | — | — | 1 | 6.40 |
| CHEMBL507236 | — | — | 1 | 6.34 |
| CHEMBL468685 | — | — | 1 | 6.31 |
| CHEMBL467705 | — | — | 1 | 6.30 |
| CHEMBL468052 | — | — | 1 | 6.30 |
| CHEMBL468676 | — | — | 1 | 6.24 |
| CHEMBL455023 | — | — | 1 | 6.08 |
| CHEMBL505807 | — | — | 1 | 6.01 |
| CHEMBL467382 | — | — | 1 | 5.89 |
| CHEMBL468686 | — | — | 1 | 5.84 |
| CHEMBL467853 | — | — | 1 | 5.31 |
| CHEMBL1454 | LEVAMISOLE | 4.0 | 1 | 4.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL461194 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL450981 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL512931 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL466808 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL467008 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL467854 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL466809 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL459706 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL445965 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL511689 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL459707 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL501296 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL466992 | — | IC50 | = | 119.0 | nM | 6.92 |
| CHEMBL459709 | — | IC50 | = | 127.0 | nM | 6.90 |
| CHEMBL461425 | — | IC50 | = | 134.0 | nM | 6.87 |
| CHEMBL459708 | — | IC50 | = | 285.0 | nM | 6.54 |
| CHEMBL502169 | — | IC50 | = | 324.0 | nM | 6.49 |
| CHEMBL445266 | — | IC50 | = | 375.0 | nM | 6.43 |
| CHEMBL509575 | — | IC50 | = | 398.0 | nM | 6.40 |
| CHEMBL507236 | — | IC50 | = | 459.0 | nM | 6.34 |
| CHEMBL468685 | — | IC50 | = | 488.0 | nM | 6.31 |
| CHEMBL467705 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL468052 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL468676 | — | IC50 | = | 574.0 | nM | 6.24 |
| CHEMBL455023 | — | IC50 | = | 828.0 | nM | 6.08 |
| CHEMBL505807 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL467382 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL468686 | — | IC50 | = | 1450.0 | nM | 5.84 |
| CHEMBL467853 | — | IC50 | = | 4850.0 | nM | 5.31 |
| CHEMBL1454 | LEVAMISOLE | Ki | = | 16000.0 | nM | 4.80 |
| CHEMBL1355736 | THEOPHYLLINE | Ki | = | 82000.0 | nM | 4.09 |