Assay Detail
Binding
CHEMBL3095060
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of wild type EGFR (unknown origin) expressed in baculovirus expression system using poly (Glu, Tyr) 4:1 as substrate after 60 mins by ELISA
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of novel 4-anilinoquinazolines with C-6 urea-linked side chains as inhibitors of the epidermal growth factor receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 6.72 | 9.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1173655 | AFATINIB | 4.0 | 1 | 9.72 |
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | 8.59 |
| CHEMBL3092313 | — | — | 1 | 7.62 |
| CHEMBL3092322 | — | — | 1 | 7.57 |
| CHEMBL3092314 | — | — | 1 | 7.50 |
| CHEMBL3092324 | — | — | 1 | 7.39 |
| CHEMBL3092308 | — | — | 1 | 7.17 |
| CHEMBL3092310 | — | — | 1 | 7.09 |
| CHEMBL3092309 | — | — | 1 | 6.78 |
| CHEMBL3092311 | — | — | 1 | 6.71 |
| CHEMBL3092304 | — | — | 1 | 6.63 |
| CHEMBL3092301 | — | — | 1 | 6.58 |
| CHEMBL3092315 | — | — | 1 | 6.55 |
| CHEMBL3092302 | — | — | 1 | 6.52 |
| CHEMBL3092303 | — | — | 1 | 6.48 |
| CHEMBL3092307 | — | — | 1 | 6.44 |
| CHEMBL3092305 | — | — | 1 | 6.39 |
| CHEMBL3092317 | — | — | 1 | 6.33 |
| CHEMBL3092321 | — | — | 1 | 6.33 |
| CHEMBL3092323 | — | — | 1 | 6.32 |
| CHEMBL3092316 | — | — | 1 | 6.30 |
| CHEMBL3092318 | — | — | 1 | 6.26 |
| CHEMBL3092312 | — | — | 1 | 6.26 |
| CHEMBL3092306 | — | — | 1 | 6.20 |
| CHEMBL3092297 | — | — | 1 | 6.16 |
| CHEMBL3092298 | — | — | 1 | 6.07 |
| CHEMBL3092299 | — | — | 1 | 6.05 |
| CHEMBL3092319 | — | — | 1 | 6.01 |
| CHEMBL3092320 | — | — | 1 | 5.80 |
| CHEMBL3092300 | — | — | 1 | 5.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1173655 | AFATINIB | IC50 | = | 0.19 | nM | 9.72 |
| CHEMBL553 | ERLOTINIB | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL3092313 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL3092322 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL3092314 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL3092324 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL3092308 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL3092310 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL3092309 | — | IC50 | = | 165.0 | nM | 6.78 |
| CHEMBL3092311 | — | IC50 | = | 197.0 | nM | 6.71 |
| CHEMBL3092304 | — | IC50 | = | 232.0 | nM | 6.63 |
| CHEMBL3092301 | — | IC50 | = | 265.0 | nM | 6.58 |
| CHEMBL3092315 | — | IC50 | = | 281.0 | nM | 6.55 |
| CHEMBL3092302 | — | IC50 | = | 304.0 | nM | 6.52 |
| CHEMBL3092303 | — | IC50 | = | 331.0 | nM | 6.48 |
| CHEMBL3092307 | — | IC50 | = | 365.0 | nM | 6.44 |
| CHEMBL3092305 | — | IC50 | = | 404.0 | nM | 6.39 |
| CHEMBL3092317 | — | IC50 | = | 464.0 | nM | 6.33 |
| CHEMBL3092321 | — | IC50 | = | 464.0 | nM | 6.33 |
| CHEMBL3092323 | — | IC50 | = | 479.0 | nM | 6.32 |
| CHEMBL3092316 | — | IC50 | = | 505.0 | nM | 6.30 |
| CHEMBL3092318 | — | IC50 | = | 543.0 | nM | 6.26 |
| CHEMBL3092312 | — | IC50 | = | 544.0 | nM | 6.26 |
| CHEMBL3092306 | — | IC50 | = | 635.0 | nM | 6.20 |
| CHEMBL3092297 | — | IC50 | = | 699.0 | nM | 6.16 |
| CHEMBL3092298 | — | IC50 | = | 859.0 | nM | 6.07 |
| CHEMBL3092299 | — | IC50 | = | 884.0 | nM | 6.05 |
| CHEMBL3092319 | — | IC50 | = | 967.0 | nM | 6.01 |
| CHEMBL3092320 | — | IC50 | = | 1581.0 | nM | 5.80 |
| CHEMBL3092300 | — | IC50 | = | 1715.0 | nM | 5.77 |