Assay Detail
Functional
CHEMBL3095061
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human A431 cells after 72 hrs by SRB assay
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-431 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of novel 4-anilinoquinazolines with C-6 urea-linked side chains as inhibitors of the epidermal growth factor receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 6.22 | 10.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1173655 | AFATINIB | 4.0 | 1 | 10.64 |
| CHEMBL3092309 | — | — | 1 | 6.94 |
| CHEMBL3092314 | — | — | 1 | 6.71 |
| CHEMBL3092317 | — | — | 1 | 6.70 |
| CHEMBL3092313 | — | — | 1 | 6.65 |
| CHEMBL3092308 | — | — | 1 | 6.61 |
| CHEMBL3092307 | — | — | 1 | 6.60 |
| CHEMBL3092310 | — | — | 1 | 6.51 |
| CHEMBL3092301 | — | — | 1 | 6.50 |
| CHEMBL3092323 | — | — | 1 | 6.41 |
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | 6.39 |
| CHEMBL3092315 | — | — | 1 | 6.35 |
| CHEMBL3092316 | — | — | 1 | 6.32 |
| CHEMBL3092322 | — | — | 1 | 6.22 |
| CHEMBL3092321 | — | — | 1 | 6.17 |
| CHEMBL3092302 | — | — | 1 | 6.12 |
| CHEMBL3092306 | — | — | 1 | 6.09 |
| CHEMBL3092299 | — | — | 1 | 6.03 |
| CHEMBL3092303 | — | — | 1 | 5.95 |
| CHEMBL3092305 | — | — | 1 | 5.85 |
| CHEMBL3092320 | — | — | 1 | 5.83 |
| CHEMBL3092324 | — | — | 1 | 5.80 |
| CHEMBL3092298 | — | — | 1 | 5.73 |
| CHEMBL3092318 | — | — | 1 | 5.71 |
| CHEMBL3092300 | — | — | 1 | 5.66 |
| CHEMBL3092297 | — | — | 1 | 5.52 |
| CHEMBL3092304 | — | — | 1 | 5.43 |
| CHEMBL3092311 | — | — | 1 | 5.39 |
| CHEMBL3092319 | — | — | 1 | 5.24 |
| CHEMBL3092312 | — | — | 1 | 4.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1173655 | AFATINIB | IC50 | = | 0.023 | nM | 10.64 |
| CHEMBL3092309 | — | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL3092314 | — | IC50 | = | 196.0 | nM | 6.71 |
| CHEMBL3092317 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3092313 | — | IC50 | = | 226.0 | nM | 6.65 |
| CHEMBL3092308 | — | IC50 | = | 247.0 | nM | 6.61 |
| CHEMBL3092307 | — | IC50 | = | 249.0 | nM | 6.60 |
| CHEMBL3092310 | — | IC50 | = | 307.0 | nM | 6.51 |
| CHEMBL3092301 | — | IC50 | = | 317.0 | nM | 6.50 |
| CHEMBL3092323 | — | IC50 | = | 387.0 | nM | 6.41 |
| CHEMBL553 | ERLOTINIB | IC50 | = | 409.0 | nM | 6.39 |
| CHEMBL3092315 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL3092316 | — | IC50 | = | 481.0 | nM | 6.32 |
| CHEMBL3092322 | — | IC50 | = | 598.0 | nM | 6.22 |
| CHEMBL3092321 | — | IC50 | = | 675.0 | nM | 6.17 |
| CHEMBL3092302 | — | IC50 | = | 759.0 | nM | 6.12 |
| CHEMBL3092306 | — | IC50 | = | 806.0 | nM | 6.09 |
| CHEMBL3092299 | — | IC50 | = | 935.0 | nM | 6.03 |
| CHEMBL3092303 | — | IC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL3092305 | — | IC50 | = | 1410.0 | nM | 5.85 |
| CHEMBL3092320 | — | IC50 | = | 1484.0 | nM | 5.83 |
| CHEMBL3092324 | — | IC50 | = | 1569.0 | nM | 5.80 |
| CHEMBL3092298 | — | IC50 | = | 1855.0 | nM | 5.73 |
| CHEMBL3092318 | — | IC50 | = | 1930.0 | nM | 5.71 |
| CHEMBL3092300 | — | IC50 | = | 2179.0 | nM | 5.66 |
| CHEMBL3092297 | — | IC50 | = | 3043.0 | nM | 5.52 |
| CHEMBL3092304 | — | IC50 | = | 3734.0 | nM | 5.43 |
| CHEMBL3092311 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL3092319 | — | IC50 | = | 5784.0 | nM | 5.24 |
| CHEMBL3092312 | — | IC50 | = | 22008.0 | nM | 4.66 |