Assay Detail
Binding
CHEMBL3095088
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Binding affinity to human HSC70 after 3 hrs by ELISA
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Heat shock cognate 71 kDa protein (CHEMBL1275223) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Analogs of the Allosteric Heat Shock Protein 70 (Hsp70) Inhibitor, MKT-077, as Anti-Cancer Agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 14 | 5.65 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3091929 | — | — | 1 | 6.40 |
| CHEMBL3091928 | — | — | 1 | 6.05 |
| CHEMBL3091931 | — | — | 1 | 6.00 |
| CHEMBL3091944 | — | — | 1 | 5.82 |
| CHEMBL3091926 | — | — | 1 | 5.77 |
| CHEMBL3091726 | — | — | 1 | 5.72 |
| CHEMBL3091941 | — | — | 1 | 5.70 |
| CHEMBL3091943 | — | — | 1 | 5.64 |
| CHEMBL3091725 | — | — | 1 | 5.62 |
| CHEMBL3091927 | — | — | 1 | 5.58 |
| CHEMBL3091728 | — | — | 1 | 5.40 |
| CHEMBL3091930 | — | — | 1 | 5.27 |
| CHEMBL3091727 | — | — | 1 | 5.11 |
| CHEMBL3091942 | — | — | 1 | 4.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3091929 | — | Kd | = | 400.0 | nM | 6.40 |
| CHEMBL3091928 | — | Kd | = | 900.0 | nM | 6.05 |
| CHEMBL3091931 | — | Kd | = | 1000.0 | nM | 6.00 |
| CHEMBL3091944 | — | Kd | = | 1500.0 | nM | 5.82 |
| CHEMBL3091926 | — | Kd | = | 1700.0 | nM | 5.77 |
| CHEMBL3091726 | — | Kd | = | 1900.0 | nM | 5.72 |
| CHEMBL3091941 | — | Kd | = | 2000.0 | nM | 5.70 |
| CHEMBL3091943 | — | Kd | = | 2300.0 | nM | 5.64 |
| CHEMBL3091725 | — | Kd | = | 2400.0 | nM | 5.62 |
| CHEMBL3091927 | — | Kd | = | 2600.0 | nM | 5.58 |
| CHEMBL3091728 | — | Kd | = | 4000.0 | nM | 5.40 |
| CHEMBL3091930 | — | Kd | = | 5400.0 | nM | 5.27 |
| CHEMBL3091727 | — | Kd | = | 7700.0 | nM | 5.11 |
| CHEMBL3091942 | — | Kd | = | 10900.0 | nM | 4.96 |